LOCALIZED EPIDERMAL NECROLYSIS (ERYTHEMA MULTIFORME-LIKE REACTION) FOLLOWING INTRAVENOUS-INJECTION OF VINBLASTINE

被引：12

作者：

ARIAS, D

REQUENA, L

HASSON, A

GUTIERREZ, M

DOMINE, M

MARTIN, L

BARAT, A

机构：

[1] INDEPENDENT UNIV MADRID,JIMENEZ DIAZ FDN,OUR LADY CONCEPT CLIN,DEPT ONCOL,MADRID,SPAIN

[2] INDEPENDENT UNIV MADRID,JIMENEZ DIAZ FDN,OUR LADY CONCEPT CLIN,DEPT PATHOL,MADRID,SPAIN

[3] INDEPENDENT UNIV MADRID,JIMENEZ DIAZ FDN,OUR LADY CONCEPT CLIN,DEPT DERMATOL,MADRID,SPAIN

来源：

JOURNAL OF CUTANEOUS PATHOLOGY | 1991年 / 18卷 / 05期

关键词：

D O I：

10.1111/j.1600-0560.1991.tb01547.x

中图分类号：

R75 [皮肤病学与性病学];

学科分类号：

100206 ;

摘要：

We report a case of localized epidermal necrolysis that developed 24 hours after an intravenous injection of vinblastine. Clinically, the lesions consisted of erythematous macules, vesicles, and bullae with a linear arrangement over the injected vein. Histologically, the lesions showed features closely resembling erythema multiforme (epidermal necrolysis). We discuss the pathogenesis of this curious cutaneous drug reaction and review the literature concerning local cutaneous complications associated with intravenously administered chemotherapeutic agents.

引用

页码：344 / 346

页数：3

共 12 条

[1] HISTOLOGIC-CHANGES INDUCED IN SKIN BY EXTRAVASATION OF DOXORUBICIN (ADRIAMYCIN) [J].