DESIGN OF ENZYME-INHIBITORS USING ITERATIVE PROTEIN CRYSTALLOGRAPHIC ANALYSIS

被引：210
作者：
APPELT, K
BACQUET, RJ
BARTLETT, CA
BOOTH, CLJ
FREER, ST
FUHRY, MAM
GEHRING, MR
HERRMANN, SM
HOWLAND, EF
JANSON, CA
JONES, TR
KAN, CC
KATHARDEKAR, V
LEWIS, KK
MARZONI, GP
MATTHEWS, DA
MOHR, C
MOOMAW, EW
MORSE, CA
OATLEY, SJ
OGDEN, RC
REDDY, MR
REICH, SH
SCHOETTLIN, WS
SMITH, WW
VARNEY, MD
VILLAFRANCA, JE
WARD, RW
WEBBER, S
WEBBER, SE
WELSH, KM
WHITE, J
机构：
[1] Agouron Pharmaceuticals, Inc., La Jolla, California 92037
来源：
JOURNAL OF MEDICINAL CHEMISTRY | 1991年 / 34卷 / 07期
关键词：
DIHYDROFOLATE-REDUCTASE INHIBITORS; RATIONAL DRUG DESIGN; THYMIDYLATE SYNTHASE; HUMAN-HEMOGLOBIN; QUINAZOLINE INHIBITOR; ACID CB3717; BINDING; SYNTHETASE; ANTIFOLATE; CELLS;
D O I：
10.1021/jm00111a001
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
[No abstract available]
引用
收藏
页码：1925 / 1934
页数：10
相关论文
共 51 条
[1]  
Albert A., 1984, The Determination of Ionization Constants. A Laboratory Manual, V3rd
[2]  
ALLEY MC, 1988, CANCER RES, V48, P589
[3]  
[Anonymous], AMBER UCSF VERSION 3
[4]   THIENOTHIOPYRAN-2-SULFONAMIDES - NOVEL TOPICALLY ACTIVE CARBONIC-ANHYDRASE INHIBITORS FOR THE TREATMENT OF GLAUCOMA [J].
BALDWIN, JJ ;
PONTICELLO, GS ;
ANDERSON, PS ;
CHRISTY, ME ;
MURCKO, MA ;
RANDALL, WC ;
SCHWAM, H ;
SUGRUE, MF ;
SPRINGER, JP ;
GAUTHERON, P ;
GROVE, J ;
MALLORGA, P ;
VIADER, MP ;
MCKEEVER, BM ;
NAVIA, MA .
JOURNAL OF MEDICINAL CHEMISTRY, 1989, 32 (12) :2510-2513
[5]   DESIGNING DRUGS TO FIT A MACROMOLECULAR RECEPTOR [J].
BEDDELL, CR .
CHEMICAL SOCIETY REVIEWS, 1984, 13 (03) :279-319
[6]   SUBSTITUTED BENZALDEHYDES DESIGNED TO INCREASE THE OXYGEN-AFFINITY OF HUMAN-HEMOGLOBIN AND INHIBIT THE SICKLING OF SICKLE ERYTHROCYTES [J].
BEDDELL, CR ;
GOODFORD, PJ ;
KNEEN, G ;
WHITE, RD ;
WILKINSON, S ;
WOOTTON, R .
BRITISH JOURNAL OF PHARMACOLOGY, 1984, 82 (02) :397-407
[7]   COMPOUNDS DESIGNED TO FIT A SITE OF KNOWN STRUCTURE IN HUMAN HEMOGLOBIN [J].
BEDDELL, CR ;
GOODFORD, PJ ;
NORRINGTON, FE ;
WILKINSON, S ;
WOOTTON, R .
BRITISH JOURNAL OF PHARMACOLOGY, 1976, 57 (02) :201-209
[8]  
BLACK JW, 1962, LANCET, V2, P311
[9]   DEFINITION AND ANTAGONISM OF HISTAMINE H2-RECEPTORS [J].
BLACK, JW ;
PARSONS, EM ;
DURANT, CJ ;
DUNCAN, WAM ;
GANELLIN, CR .
NATURE, 1972, 236 (5347) :385-&
[10]   INTERACTION OF SOME BIS-ARYLHYDROXYSULFONIC ACIDS WITH A SITE OF KNOWN STRUCTURE IN HUMAN HEMOGLOBIN [J].
BROWN, FF ;
GOODFORD, PJ .
BRITISH JOURNAL OF PHARMACOLOGY, 1977, 60 (03) :337-341
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