THE ROLE OF 3 DOMAINS IN THE BIOLOGICAL-ACTIVITY OF HUMAN INTERFERON-ALPHA

被引：78
作者：
FISH, EN [1 ]
BANERJEE, K [1 ]
STEBBING, N [1 ]
机构：
[1] ICI PLC,DIV PHARMACEUT,MACCLESFIELD SK10 4TG,CHESHIRE,ENGLAND
来源：
JOURNAL OF INTERFERON RESEARCH | 1989年 / 9卷 / 01期
关键词：
D O I：
10.1089/jir.1989.9.97
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
引用
收藏
页码：97 / 114
页数：18
相关论文
共 42 条
[1]   BIOLOGIC ACTIVITY IN A FRAGMENT OF RECOMBINANT HUMAN INTERFERON-ALPHA [J].
ACKERMAN, SK ;
NEDDEN, DZ ;
HEINTZELMAN, M ;
HUNKAPILLER, M ;
ZOON, K .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA-BIOLOGICAL SCIENCES, 1984, 81 (04) :1045-1047
[2]   ANTIGENIC STRUCTURE OF HUMAN INTERFERON-RHO-1 (INTERFERON-ALPHA-2-1) - COMPARISON WITH OTHER HUMAN INTERFERONS [J].
ADOLF, GR .
JOURNAL OF GENERAL VIROLOGY, 1987, 68 :1669-1676
[3]  
Alton K., 1983, BIOL INTERFERON SYST, P119
[4]  
ALTROCK BW, 1986, UCLA S IMMUNE REGULA, V41
[5]   PHYSICOCHEMICAL AND ANTIGENIC PROPERTIES OF SYNTHETIC FRAGMENTS OF HUMAN-LEUKOCYTE INTERFERON [J].
ARNHEITER, H ;
THOMAS, RM ;
LEIST, T ;
FOUNTOULAKIS, M ;
GUTTE, B .
NATURE, 1981, 294 (5838) :278-280
[6]   ORIENTATION OF A HUMAN-LEUKOCYTE INTERFERON MOLECULE ON ITS CELL-SURFACE RECEPTOR - CARBOXYL TERMINUS REMAINS ACCESSIBLE TO A MONOCLONAL-ANTIBODY MADE AGAINST A SYNTHETIC INTERFERON FRAGMENT [J].
ARNHEITER, H ;
OHNO, M ;
SMITH, M ;
GUTTE, B ;
ZOON, KC .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA-BIOLOGICAL SCIENCES, 1983, 80 (09) :2539-2543
[7]   FUNCTIONALLY IMPORTANT CONSERVED AMINO-ACIDS IN INTERFERON-ALPHA-2 IDENTIFIED WITH ANALOGS PRODUCED FROM SYNTHETIC GENES [J].
CAMBLE, R ;
PETTER, NN ;
TRUEMAN, P ;
NEWTON, CR ;
CARR, FJ ;
HOCKNEY, RC ;
MOORE, VE ;
GREENE, AR ;
HOLLAND, D ;
EDGE, MD .
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1986, 134 (03) :1404-1411
[8]   SYNTHESIS OF A HUMAN-LEUKOCYTE INTERFERON WITH A MODIFIED CARBOXY TERMINUS IN ESCHERICHIA-COLI [J].
CHANG, NT ;
KUNG, HF ;
PESTKA, S .
ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS, 1983, 221 (02) :585-589
[9]   CONFORMATIONAL PARAMETERS FOR AMINO-ACIDS IN HELICAL, BETA-SHEET, AND RANDOM COIL REGIONS CALCULATED FROM PROTEINS [J].
CHOU, PY ;
FASMAN, GD .
BIOCHEMISTRY, 1974, 13 (02) :211-222
[10]   INTERFERON-INDUCED PROTEIN MX ACCUMULATES IN NUCLEI OF MOUSE CELLS EXPRESSING RESISTANCE TO INFLUENZA-VIRUSES [J].
DREIDING, P ;
STAEHELI, P ;
HALLER, O .
VIROLOGY, 1985, 140 (01) :192-196
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