COMPARISON OF DIFFERENT PROTHROMBIN COMPLEX CONCENTRATES - INVITRO AND INVIVO STUDIES

被引：25

作者：

KOHLER, M ^{[1
]}

HEIDEN, M ^{[1
]}

HARBAUER, G ^{[1
]}

MIYASHITA, C ^{[1
]}

MORSDORF, S ^{[1
]}

BRAUN, B ^{[1
]}

ERNERT, P ^{[1
]}

WENZEL, E ^{[1
]}

ROSE, S ^{[1
]}

PINDUR, G ^{[1
]}

机构：

[1] UNIV SAARLAND, DEPT EXPTL SURG, W-6650 HOMBURG, GERMANY

来源：

THROMBOSIS RESEARCH | 1990年 / 60卷 / 01期

关键词：

animal model; protein C; protein S; prothrombin complex concentrate; thrombogenicity;

D O I：

10.1016/0049-3848(90)90340-I

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

The potency and tests for thrombogenicity were studied prospectively in 7 different (two lots of each brand, A - G) prothrombin complex concentrates (PCC). Human albumine (H) and a factor IX concentrate (I), served as controls. The potency of coagulation factors and inhibitors varied considerably. Two brands (E, F) contained no protein S, additionally one brand contained no protein C. Two preparations exhibited high amidolytic activities, especially towards the thrombin-sensitive chromogenic substrate S-2238, in vitro. These activities could be quenched in part by the addition of hirudin or antithrombin III. The heparin and antithrombin III content of the PCCs was significantly different, and, after addition of antithrombin III an increase of thrombin-antithrombin III complexes in 2 preparations (B, D) was observed in vitro. Additionally, three brands (B, D, F) caused more severe cardio-pulmonary reactions in rabbits, associated with an increase of fibrin split products for brands B and D. We conclude that the use of these preparations in patients, in whom an acquired protein C or S defect, or a hypercoagulable state, can be suspected, cannot be recommended. © 1990.

引用

页码：63 / 70

页数：8

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