Transcriptional Regulation of Chemokine Genes: A Link to Pancreatic Islet Inflammation?

被引：26
作者：
Burke, Susan J. [1 ]
Collier, J. Jason [1 ]
机构：
[1] Pennington Biomed Res Ctr, Lab Islet Biol & Inflammat, 6400 Perkins Rd, Baton Rouge, LA 70808 USA
来源：
BIOMOLECULES | 2015年 / 5卷 / 02期
关键词：
D O I：
10.3390/biom5021020
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Enhanced expression of chemotactic cytokines (aka chemokines) within pancreatic islets likely contributes to islet inflammation by regulating the recruitment and activation of various leukocyte populations, including macrophages, neutrophils, and T-lymphocytes. Because of the powerful actions of these chemokines, precise transcriptional control is required. In this review, we highlight what is known about the signals and mechanisms that govern the transcription of genes encoding specific chemokine proteins in pancreatic islet beta-cells, which include contributions from the NF-kappa B and STAT1 pathways. We further discuss increased chemokine expression in pancreatic islets during autoimmune-mediated and obesity-related development of diabetes.
引用
收藏
页码：1020 / 1034
页数：15
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