VITAMIN-B12 METABOLISM AND MASSIVE-DOSE METHYL VITAMIN-B12 THERAPY IN JAPANESE PATIENTS WITH MULTIPLE-SCLEROSIS

被引：39
作者：
KIRA, J
TOBIMATSU, S
GOTO, I
机构：
[1] Department of Neurology, Neurological Institute, Faculty of Medicine, Kyushu University, Fukuoka
[2] Clinical Neurophysiology, Neurological Institute, Faculty of Medicine, Kyushu University, Fukuoka
[3] Department of Neurology, Fukuoka
来源：
INTERNAL MEDICINE | 1994年 / 33卷 / 02期
关键词：
MULTIMODALITY EVOKED POTENTIALS; TRANSCOBALAMIN;
D O I：
10.2169/internalmedicine.33.82
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Serum vitamin B12 levels and unsaturated vitamin B12 binding capacities were measured in 24 patients with multiple sclerosis (MS), 73 patients with other neurological disorders and 21 healthy subjects. There was no decrease in the vitamin B12 levels, however, a significant decrease in the unsaturated vitamin B12 binding capacities was observed in patients with MS when compared with other groups. A massive dose of methyl vitamin B12 (60 mg every day for 6 months) was administered to 6 patients with chronic progressive MS, a disease which usually had a morbid prognosis and widespread demyelination in the central nervous system. Although the motor disability did not improve clinically, the abnormalities in both the visual and brainstem auditory evoked potentials improved more frequently during the therapy than in the pre-treatment period. We therefore consider that a massive dose methyl vitamin B12 therapy may be useful as an adjunct to immunosuppressive treatment for chronic progressive MS.
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页码：82 / 86
页数：5
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