E/Z DIASTEROSELECTIVE ENZYMATIC-HYDROLYSIS OF ESTERS AND DIESTERS

被引：3

作者：

SCHIRMEISTER, T ^{[1
]}

OTTO, HH ^{[1
]}

机构：

[1] UNIV FREIBURG,INST PHARMAZEUT,LS PHARMAZEUT CHEM,HERMANN HERDER STR 9,W-7800 FREIBURG,GERMANY

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION IN ENGLISH | 1993年 / 32卷 / 04期

关键词：

D O I：

10.1002/anie.199305721

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

With porcine liver esterase the α,β‐unsaturated diester 1 can be hydrolyzed selectively at the ester group in the Z position relative to the carbonyl group. The further saponification to give the dicarboxylic acid is achieved with aqueous NaOH. However, even under drastic conditions, 1 cannot be hydrolyzed in one step by either bases or acids with retention of the β‐lactam ring. (Figure Presented.) Copyright © 1993 by VCH Verlagsgesellschaft mbH, Germany

引用

页码：572 / 574

页数：3

共 17 条

[1]

AKITA H, 1989, CHEM PHARM BULL, V37, P2876

[2] THE EFFECT OF DIMETHYLSULFOXIDE ON THE ENANTIOSELECTIVITY IN THE PIG-LIVER ESTERASE CATALYZED-HYDROLYSIS OF DIALKYLATED PROPANEDIOIC ACID DIMETHYL ESTERS [J].