Electrical stimulation enhances reinnervation after nerve injury

被引：32
|
作者：
Willand, Michael P. [1 ]
机构：
[1] Hosp Sick Children, Dept Surg, Div Plast Reconstruct Surgery, Toronto, ON M5G 1X8, Canada
来源：
EUROPEAN JOURNAL OF TRANSLATIONAL MYOLOGY | 2015年 / 25卷 / 04期
关键词：
Electrical muscle stimulation; nerve injury; axon sprouting; motor unit number estimation; EMG; intramuscular neurotrophic factors;
D O I：
10.4081/ejtm.2015.5243
中图分类号：
R-3 [医学研究方法]; R3 [基础医学];
学科分类号：
1001 ;
摘要：
Electrical muscle stimulation following peripheral nerve injury has been a controversial method of treatment due primarily to the inconsistent literature surrounding it. In this presentation transcript I outline ongoing experiments investigating a clinically translatable daily muscle stimulation paradigm in rats following nerve injury. Results show that reinnervation of muscle and functional behavioural metrics are enhanced with daily stimulation with upregulation of intramuscular neurotrophic factors as a potential mechanism. In addition, the impact of stimulation on terminal sprouting, a mentioned negative aspect of electrical muscle stimulation, was a minor contributor to long term functional reinnervation of stimulated muscles in our studies.
引用
收藏
页码：243 / 248
页数：6
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