SKN-1A AND SKN-1I - 2 FUNCTIONALLY DISTINCT OCT-2-RELATED FACTORS EXPRESSED IN EPIDERMIS

被引：108
作者：
ANDERSEN, B [1 ]
SCHONEMANN, MD [1 ]
FLYNN, SE [1 ]
PEARSE, RV [1 ]
SINGH, H [1 ]
ROSENFELD, MG [1 ]
机构：
[1] UNIV CHICAGO,HOWARD HUGHES MED INST,CHICAGO,IL 60637
来源：
SCIENCE | 1993年 / 260卷 / 5104期
关键词：
D O I：
10.1126/science.7682011
中图分类号：
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
Two forms of a member of the POU domain family of transcriptional regulators, highly related to Oct-2, are selectively expressed in terminally differentiating epidermis and hair follicles. One form, referred to as Skn-1i, contains an amino-terminal domain that inhibits DNA binding and can inhibit transactivation by Oct-1. A second form, Skn-1a, contains an alternative amino terminus and serves to activate cytokeratin 10 (K10) gene expression. The pattern of expression of the Skn-1a/i gene products and the effect of the alternative products on the expression of other genes suggest that these factors serve regulatory functions with respect to epidermal development.
引用
收藏
页码：78 / 82
页数：5
相关论文
共 59 条
[41]   REGULATION OF TRANSCRIPTION AND CELL IDENTITY BY POU DOMAIN PROTEINS [J].
RUVKUN, G ;
FINNEY, M .
CELL, 1991, 64 (03) :475-478
[42]   DNA SEQUENCING WITH CHAIN-TERMINATING INHIBITORS [J].
SANGER, F ;
NICKLEN, S ;
COULSON, AR .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1977, 74 (12) :5463-5467
[43]   A HUMAN LYMPHOID-SPECIFIC TRANSCRIPTION FACTOR THAT ACTIVATES IMMUNOGLOBULIN GENES IS A HOMOEOBOX PROTEIN [J].
SCHEIDEREIT, C ;
CROMLISH, JA ;
GERSTER, T ;
KAWAKAMI, K ;
BALMACEDA, CG ;
CURRIE, RA ;
ROEDER, RG .
NATURE, 1988, 336 (6199) :551-557
[44]   OCTAMANIA - THE POU FACTORS IN MURINE DEVELOPMENT [J].
SCHOLER, HR .
TRENDS IN GENETICS, 1991, 7 (10) :323-329
[45]  
SIMMONS DM, 1989, J HISTOTECHNOL, V12, P169
[46]   A 100-KD HELA-CELL OCTAMER BINDING-PROTEIN (OBP100) INTERACTS DIFFERENTLY WITH 2 SEPARATE OCTAMER-RELATED SEQUENCES WITHIN THE SV40 ENHANCER [J].
STURM, R ;
BAUMRUKER, T ;
FRANZA, BR ;
HERR, W .
GENES & DEVELOPMENT, 1987, 1 (10) :1147-1160
[47]   THE POU DOMAIN IS A BIPARTITE DNA-BINDING STRUCTURE [J].
STURM, RA ;
HERR, W .
NATURE, 1988, 336 (6199) :601-604
[48]   THE UBIQUITOUS OCTAMER-BINDING PROTEIN OCT-1 CONTAINS A POU DOMAIN WITH A HOMEO BOX SUBDOMAIN [J].
STURM, RA ;
DAS, G ;
HERR, W .
GENES & DEVELOPMENT, 1988, 2 (12A) :1582-1599
[49]   AN INHIBITORY DOMAIN OF E12 TRANSCRIPTION FACTOR PREVENTS DNA-BINDING IN E12 HOMODIMERS BUT NOT IN E12 HETERODIMERS [J].
SUN, XH ;
BALTIMORE, D .
CELL, 1991, 64 (02) :459-470
[50]   ACTIVATION OF THE U2 SNRNA PROMOTER BY THE OCTAMER MOTIF DEFINES A NEW CLASS OF RNA POLYMERASE-II ENHANCER ELEMENTS [J].
TANAKA, M ;
GROSSNIKLAUS, U ;
HERR, W ;
HERNANDEZ, N .
GENES & DEVELOPMENT, 1988, 2 (12B) :1764-1778
123456