POLYMYXIN-B AND HEART-MUSCLE

被引：1
|
作者：
SOHN, YZ
KATZ, RL
机构：
[1] Department of Anesthesiology, University of California at Los Angeles, School of Medicine
来源：
BRITISH JOURNAL OF ANAESTHESIA | 1979年 / 51卷 / 11期
关键词：
D O I：
10.1093/bja/51.11.1035
中图分类号：
R614 [麻醉学];
学科分类号：
100217 ;
摘要：
The effects of the polypeptide antibiotic, polymyxin B, on myocardial contractility were studied in the isolated rat heart muscle. Five different doses of polymyxin B were tested. There were no changes in contractility with doses ranging from the clinical therapeutic value to three times greater. There was an initial increase and then depression with a dose six times greater than the therapeutic dose. There was no direct competitive interaction between polymyxin B and halothane or Ca2+. This suggests that polymyxin B does not depress the myocardium in clinical doses and does not interfere with Ca2+ influx at the myocardial cell membrane. © 1979 Macmillan Journals Ltd.
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页码：1035 / 1040
页数：6
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