PROGNOSTIC SIGNIFICANCE OF THE HISTOLOGICAL FEATURES OF MALIGNANT-MELANOMA

被引：156
作者：
MCGOVERN, VJ
SHAW, HM
MILTON, GW
FARAGO, GA
机构：
[1] SYDNEY HOSP,MELANOMA CLIN,SYDNEY 2000,NEW S WALES,AUSTRALIA
[2] ROYAL PRINCE ALFRED HOSP,FAIRFAX INST PATHOL,CAMPERDOWN 2050,NEW S WALES,AUSTRALIA
[3] UNIV SYDNEY,DEPT SURG,SYDNEY 2006,NEW S WALES,AUSTRALIA
来源：
HISTOPATHOLOGY | 1979年 / 3卷 / 05期
关键词：
malignant melanoma; mitotic activity; nodular melanoma; prognosis; regression; superficial spreading melanoma; tumour thickness;
D O I：
10.1111/j.1365-2559.1979.tb03020.x
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
A review of 694 patients with localized cutaneous malignant melanoma (clinical stage I) revealed that three histological features of the primary lesion had no effect of their own on survival rate but derived their prognostic significance only because of their close correlation with tumour thickness. Primary lesions of superficial spreading histogenetic type, or of low mitotic activity or showing evidence of partial regression appeared to have a more favourable prognosis than lesions of nodular histogenetic type or of high mitotic activity or showing no regression. However, the former three histological features were predominant in thin lesions which had a better prognosis than thicker lesions. It was concluded that these features exerted only an indirect effect upon survival, tumour thickness being the most important prognostic determinant. Copyright © 1979, Wiley Blackwell. All rights reserved
引用
收藏
页码：385 / 393
页数：9
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