AUTORADIOGRAPHIC LOCALIZATION OF 2-[I-125]IODOMELATONIN BINDING-SITES IN THE BRAINS OF C3H-HEN AND C57BL/6J STRAINS OF MICE

被引：64

作者：

SIUCIAK, JA ^{[1
]}

FANG, JM ^{[1
]}

DUBOCOVICH, ML ^{[1
]}

机构：

[1] NORTHWESTERN UNIV,DEPT PHARMACOL,303 E CHICAGO AVE,CHICAGO,IL 60611

来源：

EUROPEAN JOURNAL OF PHARMACOLOGY | 1990年 / 180卷 / 2-3期

关键词：

2-[[!sup]125[!/sup]I]Iodomelatonin; C57BL/6J mice; C[!sub]3[!/sub]H/HeN; Melatonin; Receptor autoradiography;

D O I：

10.1016/0014-2999(90)90328-4

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The present study uses in vitro autoradiography to localize 2-[125I]iodemelatonin binding sites in the brain of two strains of mice, the C3H/HeN and the C57BL/6J, which have been shown to exhibit differences in pineal melatonin content. We found a differential pattern of distribution of 2-[125I]iodomelatonin binding sites between the two strains with the suprachiasmatic nucleus, paraventricular nucleus of the thalamus, regions labelled in both strains. These studies should help to interpret behavioral changes due to activation of melatonin receptors in these strains of mice. © 1990.

引用

页码：387 / 390

页数：4

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