ANTI-VIRAL IMMUNITY AGAINST MAREKS-DISEASE VIRUS-INFECTED CHICKEN KIDNEY CELLS

被引：28

作者：

KODAMA, H

SUGIMOTO, C

INAGE, F

MIKAMI, T

机构：

[1] Department of Epizootiology, Faculty of Veterinary Medicine, Hokkaido University, Sapporo 060, N.18

来源：

AVIAN PATHOLOGY | 1979年 / 8卷 / 01期

关键词：

D O I：

10.1080/03079457908418325

中图分类号：

S85 [动物医学（兽医学）];

学科分类号：

0906 ;

摘要：

The mechanism of immunity conferred by herpesvirus of turkeys (HVT) was investigated using Marek's disease virus (MDV) infected chicken kidney cell (CKC) cultures as target cells. Peripheral blood lymphocytes (PBL) from normal or HVT-vaccinated chickens killed MDV infected target cells in the presence of anti-MDV or anti-HVT serum, whereas normal lymphocytes and HVT-sensitised lymphocytes themselves had no specific cytotoxic effect. Cell-mediated cytotoxicity of PBL from HVT-vaccinated chicken was exhibited specifically against HVT infected CKC, and that of PBL from chickens inoculated with MDV was exhibited against MDV infected CKC. From these results, it was concluded that antibody-dependent cellular cytotoxicity to MDV infected cells may contribute to resistance to Marek's disease induced by HVT vaccination. © 1979, Taylor & Francis Group, LLC. All rights reserved.

引用

页码：33 / 44

页数：12

共 26 条

[1]

ADLDINGER HK, 1977, ONCOGENESIS HERPESVI, V3

[2]

BRUNNER KT, 1970, IMMUNOLOGY, V18, P501

[3] AGENT OF MAREKS DISEASE IN TISSUE CULTURE [J].