MICROBIAL OXIDATION IN SYNTHESIS - PREPARATION OF MYOINOSITOL PHOSPHATES AND RELATED CYCLITOL DERIVATIVES FROM BENZENE

被引：86
作者：
LEY, SV
PARRA, M
REDGRAVE, AJ
STERNFELD, F
机构：
[1] Department of Chemistry, Imperial College of Science, Technology and Medicine, London
来源：
TETRAHEDRON | 1990年 / 46卷 / 13-14期
关键词：
D O I：
10.1016/S0040-4020(01)85605-2
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
Pseudomonas putida oxidation of benzene affords cis-3,5-cyclohexadiene-1,2-diol (2) which is used as a novel precursor for the synthesis of D- and L-myo-inositol 1,4,5-trisphosphates, (-)-(1) and (+)-(1). The versatility of this approach to functionalised cyclitols is illustrated in the synthesis of -inositol l-phosphate (19), 6-deoxy, 6-deoxy-6-fluoro, and 6-deoxy-6-methyl myo- inositols (31), (37) and (43), and their 1,4,5-trisphosphate derivatives (33), (39) and (45). © 1990.
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页码：4995 / 5026
页数：32
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