Novel Synthesis of Fused Pyrazolopyrimidines and C-Nucleosides of Thienopyrimidone with Expected Antimicrobial Activity

被引：0
作者：
Hussein, H. A. R. [1 ]
Abu-Zied, Kh. M. [1 ]
Abu-Hashem, A. A. [1 ]
机构：
[1] Natl Res Ctr, Dept Photochem, Heterocycl Unit, Cairo, Egypt
来源：
EGYPTIAN JOURNAL OF CHEMISTRY | 2010年 / 53卷 / 04期
关键词：
Pyrazolopyrimidine; C-Nucleosides; NMR spectra; Mass spectra; Antibacterial and Antifungal Activities;
D O I：
暂无
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
STARTING from thienopyrimidine hydrazine derivatives (1a, d) and (2b, c) a series of pyrazolopyrimidine derivatives has been synthesized. Also, some acyclic and cyclic C-nucleosides of thienopyrimidone (7-10) were prepared by treating compound 1a with aldoses. The prepared products showed antimicrobial activity. Structures of the new compounds were elucidated on the basis of their elemental analyses and spectral data.
引用
收藏
页码：527 / 540
页数：14
相关论文
共 39 条
  • [21] Synthesis of pyrido[2,3-d]pyrimidine (5-deazapteridine) C-nucleosides from a glycosyl enaminone
    Maeba, I
    Nishiyama, Y
    Wakimura, M
    Tabata, T
    CARBOHYDRATE RESEARCH, 1996, 290 (01) : 71 - 77
  • [22] A versatile protocol for the synthesis of oxazole and 3-nitro/3-carbethoxy pyrrole C-nucleosides using TOSMIC
    Krishna, PR
    Reddy, VVR
    Sharma, GVM
    SYNLETT, 2003, (11) : 1619 - 1622
  • [23] Dye-sensitized photooxygenation of sugar-furans as synthetic strategy for novel C-nucleosides and functionalized exo-glycals
    Cermola, Flavio
    Iesce, M. Rosaria
    TETRAHEDRON, 2006, 62 (46) : 10694 - 10699
  • [24] Efficient synthesis of novel 2-deoxy-C-nucleosides containing oxa and thiadiazole derivatives and their biological activity
    Penjarla, Srishylam
    Reddy, Paidi Yella
    Penta, Santhosh
    Sanghvi, Yogesh S.
    Eyer, Ludek
    Stefanik, Michal
    Ruzek, Daniel
    Banerjee, Shyamapada
    JOURNAL OF MOLECULAR STRUCTURE, 2023, 1292
  • [25] Novel epimerization of aromatic C-nucleosides with electron-withdrawing substituents with trifluoroacetic acid-benzenesulfonic acid using mild conditions
    Jiang, YL
    Stivers, JT
    TETRAHEDRON LETTERS, 2003, 44 (21) : 4051 - 4055
  • [26] Asymmetric synthesis of (2′R,4′R) and (2′S,4′S)-1,3-dioxolanyl triazole C-nucleosides
    Qu, FC
    Hong, JH
    Du, JF
    Newton, MG
    Chu, CK
    TETRAHEDRON, 1999, 55 (30) : 9073 - 9088
  • [27] Synthesis and antimicrobial activity of novel 1,5-benzodiazepines
    Ilango, S. S.
    Remya, P. U.
    Ponnuswamy, S.
    INDIAN JOURNAL OF CHEMISTRY SECTION B-ORGANIC CHEMISTRY INCLUDING MEDICINAL CHEMISTRY, 2013, 52 (01): : 136 - 140
  • [28] Synthesis and Biological Properties of 5-(1H-1,2,3-Triazol-4-yl)isoxazolidines: A New Class of C-Nucleosides
    Giofre, Salvatore V.
    Romeo, Roberto
    Carnovale, Caterina
    Mancuso, Raffaella
    Cirmi, Santa
    Navarra, Michele
    Garozzo, Adriana
    Chiacchio, Maria A.
    MOLECULES, 2015, 20 (04) : 5260 - 5275
  • [29] Anti-norovirus activity of C7-modified 4-amino-pyrrolo[2,1-f][1,2,4]triazine C-nucleosides
    Li, Qingfeng
    Groaz, Elisabetta
    Rocha-Pereira, Joana
    Neyts, Johan
    Herdewijn, Piet
    EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2020, 195
  • [30] Synthesis, in Vivo Anti-inflammatory, and in Vitro Antimicrobial Activity of New 5-Benzofuranyl Fused Pyrimidines
    Nassar, Ekhlass
    El-Badry, Yaser Abdel-Moemen
    El Kazazel, Hagar
    CHEMICAL & PHARMACEUTICAL BULLETIN, 2016, 64 (06) : 558 - 563
1234