PRIMARY AND SECONDARY LIVER/KIDNEY MICROSOMAL AUTOANTIBODY RESPONSE FOLLOWING INFECTION WITH HEPATITIS-C VIRUS

被引:64
作者
MACKIE, FD
PEAKMAN, M
YUN, M
SALLIE, R
SMITH, H
DAVIES, ET
MIELIVERGANI, G
VERGANI, D
机构
[1] UNIV LONDON KINGS COLL, SCH MED & DENT, DEPT IMMUNOL, LONDON SE5 9PJ, ENGLAND
[2] UNIV LONDON KINGS COLL, SCH MED & DENT, DEPT CHILD HLTH, LONDON WC2R 2LS, ENGLAND
[3] UNIV LONDON KINGS COLL, SCH MED & DENT, INST LIVER STUDIES, LONDON WC2R 2LS, ENGLAND
基金
英国惠康基金;
关键词
D O I
10.1016/0016-5085(94)90426-X
中图分类号
R57 [消化系及腹部疾病];
学科分类号
摘要
Liver/kidney microsomal autoantibody type 1 (LKM-1), which characterizes a subtype of autoimmune hepatitis, is also found in some patients with chronic hepatitis C virus (HCV) infection. Whether HCV and LKM-1 are accidentally or causally related is unknown. This case report describes a child who became infected by HCV after liver transplantation for end-stage liver disease caused by α1-antitrypsin deficiency. LKM-1 was detected by immunofluorescence, anti-microsomal reactivity by Western blotting, anti-HCV and anti-GOR by immunoenzymatic assays, and HCV RNA by polymerase chain reaction. Two weeks after HCV infection, immunoglobulin (lg) M LKM-1 appeared, followed by lgG1 LKM-1, with titers increasing to 1/2560; antibodies to a 50-kilodalton liver microsomal protein appeared 2 months later. Sera from day 1 posttransplant became positive for HCV RNA. HCV RNA was also detected in a liver biopsy specimen obtained 3 months after surgery. The patient did not produce anti-HCV and anti-GOR antibodies throughout the study and had no histological evidence of hepatitis. The temporal relationship between HCV infection and LKM-1 production suggests that HCV may trigger a primary autoimmune response. The lack of liver damage attributable to autoimmunity or viral infection may be caused by immunosuppression. © 1994.
引用
收藏
页码:1672 / 1675
页数:4
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