PROTEIN-KINASE C-ALPHA INHIBITORS - STRUCTURE-ACTIVITY-RELATIONSHIPS IN BIS-INDOLE SERIES

被引：9

作者：

XIE, GJ

ZIMMERMANN, J

MEYER, T

LOWN, JW

机构：

[1] UNIV ALBERTA,DEPT CHEM,EDMONTON,AB T6G 2G2,CANADA

[2] CIBA GEIGY AG,DIV PHARMACEUT,CH-4002 BASEL,SWITZERLAND

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1995年 / 5卷 / 05期

关键词：

D O I：

10.1016/0960-894X(95)00060-7

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

To assess the role of the amine and ester containing oligopeptide side-chains in bis-indole protein kinase C inhibitors, six novel hybrids in this series were synthesized. These new compounds displayed effective inhibitory activity against protein kinase C-alpha.

引用

收藏

页码：497 / 500

页数：4

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