MAJOR HISTOCOMPATIBILITY COMPLEX CLASS-II ANTIGENS IN STEROID-SENSITIVE NEPHROTIC SYNDROME IN CHINESE CHILDREN

被引：20

作者：

ZHOU, GP ^{[1
]}

GUO, YQ ^{[1
]}

JI, YH ^{[1
]}

ZHANG, GL ^{[1
]}

机构：

[1] SHANGHAI INST BLOOD TRANSFUS,DEPT IMMUNOGENET,SHANGHAI,PEOPLES R CHINA

来源：

PEDIATRIC NEPHROLOGY | 1994年 / 8卷 / 02期

关键词：

NEPHROTIC SYNDROME; MAJOR HISTOCOMPATIBILITY COMPLEX; IMMUNOGENETICS;

D O I：

10.1007/BF00865460

中图分类号：

R72 [儿科学];

学科分类号：

100202 ;

摘要：

Steroid-sensitive nephrotic syndrome (SSNS) has been postulated to have an immunopathogenic basis. To determine whether SSNS is associated with specific class II antigens of the major histocompatibility complex, we studied HLA-DR and DQ in 40 children with SSNS. HLA-DR7 was found in 40% of SSNS patients compared with only 11.23% of controls (P = 0.00025). HLA-DR9 occurred in 71.40% of patients with frequent relapses, compared with 27.37% of controls (P = 0.016). It seems likely that SSNS has an immunogenetic basis.

引用

页码：140 / 141

页数：2

共 14 条

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