THE BCL-2 GENE FAMILY

被引：129
作者：
CRAIG, RW
机构：
[1] Dept. of Pharmacology and Toxicology, Dartmouth Medical School, Hanover
来源：
SEMINARS IN CANCER BIOLOGY | 1995年 / 6卷 / 01期
关键词：
BCL-2; BCL-X; BAX; MCL-1; CED9;
D O I：
10.1006/scbi.1995.0005
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Viability is a fundamental determinant of all cellular functions, and regulation of cell viability is important in shaping tissue differentiation and organism development. The genes in the bcl-2 family can profoundly influence cell viability. In addition to bcl-2, cellular genes in this family include bcl-x, bax, mcl-1, and A1 (from vertebrates), as well as ced9 (from Caenorhabditis elegans). Different members of the family exhibit a spectrum of activity, ranging from survival-enhancement to death-enhancement. Thus, the combinatorial effects of various bcl-2 family members may allow a fine level of control over the important function of cell viability. In addition, alterations in these genes may cause aberations in cell death and thus contribute to cancer.
引用
收藏
页码：35 / 43
页数：9
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