MECHANISMS OF EGF RECEPTOR REGULATION IN BREAST-CANCER CELLS

被引：37
作者：
CHRYSOGELOS, SA
YARDEN, RI
LAUBER, AH
MURPHY, JM
机构：
[1] GEORGETOWN UNIV,DEPT BIOCHEM & MOLEC BIOL,WASHINGTON,DC 20007
[2] MAYO CLIN & MAYO FDN,DEPT BIOCHEM & MOLEC BIOL,ROCHESTER,MN 55905
来源：
BREAST CANCER RESEARCH AND TREATMENT | 1994年 / 31卷 / 2-3期
关键词：
BREAST CANCER; EPIDERMAL GROWTH FACTOR RECEPTOR; GENE EXPRESSION; HORMONE-INDEPENCE;
D O I：
10.1007/BF00666156
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Overexpression of the EGF receptor in breast cancer correlates with poor prognosis and failure on endocrine therapy for both ER-/EGFR+ and ER+/EGFR+ tumors, suggesting a role for EGFR in the progression to hormone independence. The identification of specific DNase I hypersensitive site patterns for the EGFR gene in ER+ vs. ER- cells implicates regions of the EGFR first intron in up-regulation of EGFR, while estrogen regulation studies indicate the involvement of a repressor(s) in the maintenance of low levels of EGFR. Based on these findings, a multi-step model is proposed for the progression of breast cancer from a hormone-dependent, ER+/EGFR- phenotype to an aggressive, hormone-independent, ER-/EGFR+ stage.
引用
收藏
页码：227 / 236
页数：10
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