AN ANCIENT FAMILY OF EMBRYONICALLY EXPRESSED MOUSE GENES SHARING A CONSERVED PROTEIN MOTIF WITH THE T-LOCUS

被引：194

作者：

BOLLAG, RJ ^{[1
]}

SIEGFRIED, Z ^{[1
]}

CEBRATHOMAS, JA ^{[1
]}

GARVEY, N ^{[1
]}

DAVIDSON, EM ^{[1
]}

SILVER, LM ^{[1
]}

机构：

[1] PRINCETON UNIV,DEPT MOLEC BIOL,PRINCETON,NJ 08544

来源：

NATURE GENETICS | 1994年 / 7卷 / 03期

关键词：

D O I：

10.1038/ng0794-383

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

The T locus encodes a product with DNA binding activity that is likely to play a role in the development of all vertebrate organisms. We have identified and characterized a novel family of mouse genes that share a protein motif, the T-box, with the prototypical T locus. The T-box domain of the T locus co-localizes with its DNA binding activity. Each T-box gene is expressed in a unique temporal and spatial pattern during embryogenesis. Phylogenetic analysis suggests that at least three T-box genes were present in the common ancestor to vertebrates and invertebrates. Thus, members of the T-box family could have played a role in the evolution of all metazoan organisms.

引用

页码：383 / 389

页数：7

共 23 条

[1] SINGLE-STEP METHOD OF RNA ISOLATION BY ACID GUANIDINIUM THIOCYANATE PHENOL CHLOROFORM EXTRACTION [J].