INDUCTION OF PC12 CELL-DEATH, APOPTOSIS, BY A SIALOGLYCOPEPTIDE FROM BOVINE BRAIN

被引：16
|
作者：
KOBAYASHI, Y [1 ]
SAHEKI, T [1 ]
SHINOZAWA, T [1 ]
机构：
[1] GUNMA UNIV,FAC ENGN,DEPT BIOL & CHEM ENGN,KIRYU,GUMMA 376,JAPAN
来源：
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 1994年 / 203卷 / 03期
关键词：
D O I：
10.1006/bbrc.1994.2363
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The sialoglycopeptide from bovine bl ain inhibited the growth of PC12 cells in the presence of nerve growth factor. This inhibition was accompanied by DNA fragmentation showing a ladder pattern and changes in cell morphology leading to cytoplasmic condensation. These results suggest that the sialoglycopeptide induces PC12 cell apoptosis in the presence of nerve growth factor. (C) 1994 Academic Press, Inc.
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收藏
页码：1554 / 1559
页数：6
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