A 28 KDA-PROTEIN WITH DISINTEGRIN-LIKE STRUCTURE (JARARHAGIN-C) PURIFIED FROM BOTHROPS-JARARACA VENOM INHIBITS COLLAGEN-INDUCED AND ADP-INDUCED PLATELET-AGGREGATION

被引：114
|
作者：
USAMI, Y
FUJIMURA, Y
MIURA, S
SHIMA, H
YOSHIDA, E
YOSHIOKA, A
HIRANO, K
SUZUKI, M
TITANI, K
机构：
[1] FUJITA HLTH UNIV, INST COMPREHENS MED SCI, DIV BIOMED POLYMER SCI, TOYOAKE, AICHI 47011, JAPAN
[2] GIFU PHARMACEUT UNIV, DEPT PHARMACEUT, GIFU 502, JAPAN
[3] NARA MED UNIV, DEPT BLOOD TRANSFUS, KASHIHARA, NARA 634, JAPAN
来源：
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 1994年 / 201卷 / 01期
关键词：
D O I：
10.1006/bbrc.1994.1706
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
A 28 kDa-protein with inhibitory activity on collagen- and ADP-induced platelet aggregation was purified from the venom of the snake Bothrops jararaca. Its complete amino acid sequence corresponded to the carboxyl-terminal region consisting of disintegrin-like and cysteine-rich domains of jararhagin, a high molecular weight hemorrhagic metalloprotease. Sequence homology of the protein to other disintegrins and disintegrin-like proteins from various snake venoms is also presented. (C) 1994 Academic Press, Inc.
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收藏
页码：331 / 339
页数：9
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