MOLECULAR EVALUATION OF RESIDUAL DISEASE AS A PREDICTOR OF RELAPSE IN ACUTE PROMYELOCYTIC LEUKEMIA

被引：207

作者：

LOCOCO, F

DIVERIO, D

PANDOLFI, PP

BIONDI, A

ROSSI, V

AVVISATI, G

RAMBALDI, A

ARCESE, W

PETTI, MC

MELONI, G

MANDELLI, F

GRIGNANI, F

MASERA, G

BARBUI, T

PELICCI, PG

机构：

[1] IST MARIO NEGRI,BERGAMO,ITALY

[2] UNIV PERUGIA,MONTELUCE POLICLIN,I-06100 PERUGIA,ITALY

[3] UNIV MILAN,PEDIAT CLIN,I-20122 MILAN,ITALY

来源：

LANCET | 1992年 / 340卷 / 8833期

关键词：

D O I：

10.1016/0140-6736(92)92625-P

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Acute promyelocytic leukaemia (APL) is characterised by a unique fusion transcript, PML/RARalpha. We tested for this transcript in 35 APL patients who were in apparent remission after various treatments. 11 of 13 patients who tested positive 4 months after achieving remission were in relapse 1-4 months later. All 22 patients who tested negative at 4 months were disease-free after a further 3 months to five years. The test may therefore prove useful in determining the need for additional treatment during clinical remission.

引用

页码：1437 / 1438

页数：2

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