PRIMING STIMULATION FACILITATES HEBB-TYPE PLASTICITY IN THE SCHAFFER COLLATERAL-COMMISSURAL PATHWAYS OF THE MOUSE HIPPOCAMPUS

被引：0
|
作者：
FEDOROV, NB [1 ]
SERGEEVA, OA [1 ]
SKREBITSKY, VG [1 ]
机构：
[1] RUSSIAN ACAD MED SCI,INST BRAIN RES,MOSCOW,RUSSIA
来源：
EXPERIMENTAL BRAIN RESEARCH | 1993年 / 94卷 / 02期
关键词：
HIPPOCAMPUS; HEBB-TYPE PLASTICITY; PRIMING STIMULATION;
D O I：
暂无
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
Hebb-type plastic changes of synaptic trans mission were analyzed in the Schaffer collateral-commissural pathways (SC) of the mouse hippocampal slice. Low frequency (0.05-0.1 Hz) SC stimulation (S2) was paired with intracellular depolarization (100-200 ms; 2-3 nA) of CA1 pyramidal. Postpairing facilitation of synaptic responses in picrotoxin-free medium occurred only when S2 was ''primed'' with neurons the preceding shock (S1) administered through the same electrode 200 ms before S2. Priming-determined disinhibition in local circuitry is supposed to be responsible for this phenomenon.
引用
收藏
页码：270 / 272
页数：3
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