C-ERBB3 GENE ENCODES SECRETED AS WELL AS TRANSMEMBRANE RECEPTOR TYROSINE KINASE

被引：61

作者：

KATOH, M ^{[1
]}

YAZAKI, Y ^{[1
]}

SUGIMURA, T ^{[1
]}

TERADA, M ^{[1
]}

机构：

[1] UNIV TOKYO, FAC MED,DEPT INTERNAL MED 3,HONGO 7-3-1,BUNKYO KU, TOKYO 113, JAPAN

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 1993年 / 192卷 / 03期

关键词：

D O I：

10.1006/bbrc.1993.1542

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

c-erbB3 product is moderately expressed in gastric mucosa, especially in parietal cells. Northern blot analysis revealed that 6.2-kb c-erb83 transcnpt was expressed in all gasteric cancer cell lines examined, and that 1.4-kb c-erbB3 transcnpt was expressed as highly as 6.2-kb transcript in MKN45 cells. erbB3-S cDNA, corresponding to 1.4-kb c-erbB3 transcript, was cloned by rapid amplification of cDNA ends. Sequence analysis of erbB3-S cDNA showed that this 1.4-kb c-erbB3 mRNA encoded a secreted receptor. Analysis of partial genomic structure of c-erbB3 gene revealed that the exon specific to secreted receptor was identical with the 5′ portion of the intron in c-erbB3 gene. c-erbB3 gene encodes secreted as well as transmembrane receptor tyrosine kinase due to alternative splicing. © 1993 Academic Press. All rights reserved.

引用

页码：1189 / 1197

页数：9

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