AMYLOID PRECURSOR PROTEIN IS FOUND IN LYSOSOMES

被引：0

作者：

TAGAWA, K

YAZAKI, M

KINOUCHI, T

MARUYAMA, K

SORIMACHI, H

TSUCHIYA, T

SUZUKI, K

ISHIURA, S

机构：

[1] UNIV TOKYO,INST MOLEC & CELLULAR BIOSCI,TOKYO 113,JAPAN

[2] SOPHIA UNIV,FAC SCI & TECHNOL,DEPT CHEM,TOKYO 102,JAPAN

[3] TOKYO METROPOLITAN INST MED SCI,TOKYO 113,JAPAN

来源：

GERONTOLOGY | 1993年 / 39卷

关键词：

AMYLOID; AMYLOID PRECURSOR PROTEIN (APP); LYSOSOME; SENILE PLAQUE; ALZHEIMERS DISEASE; PROCESSING; PROTEINASE; NEURON; ASTROCYTE;

D O I：

暂无

中图分类号：

R592 [老年病学]; C [社会科学总论];

学科分类号：

03 ; 0303 ; 100203 ;

摘要：

The major component of Alzheimer's disease amyloid is a small polypeptide referred as the amyloid beta protein, which is derived from a larger precursor, amyloid Precursor protein (APP). Cell fractionation and immunological studies on the APP molecule indicate that APP is localized either in the neuron and astrocyte and that the molecule is recovered from lysosomal fraction.

引用

页码：24 / 29

页数：6

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