A LINKAGE MAP OF HUMAN CHROMOSOME-21 - 43 PCR MARKERS AT AVERAGE INTERVALS OF 2.5 CM

被引：94

作者：

MCINNIS, MG

CHAKRAVARTI, A

BLASCHAK, J

PETERSEN, MB

SHARMA, V

AVRAMOPOULOS, D

BLOUIN, JL

KONIG, U

BRAHE, C

MATISE, TC

WARREN, AC

TALBOT, CC

VAN BROECKHOVEN, C

LITT, M

ANTONARAKIS, SE

机构：

[1] JOHNS HOPKINS UNIV, SCH MED, DEPT PEDIAT, 600 N WOLFE ST, CMSC 1004, BALTIMORE, MD 21287 USA

[2] JOHNS HOPKINS UNIV, SCH MED, CTR MED GENET, BALTIMORE, MD 21287 USA

[3] JOHNS HOPKINS UNIV, SCH MED, DEPT PSYCHIAT, BALTIMORE, MD 21287 USA

[4] JOHNS HOPKINS UNIV, SCH MED, DEPT MED, BALTIMORE, MD 21287 USA

[5] UNIV PITTSBURGH, DEPT HUMAN GENET, PITTSBURGH, PA 15261 USA

[6] UNIV PITTSBURGH, DEPT PSYCHIAT, PITTSBURGH, PA 15261 USA

[7] DANISH CTR HUMAN GENOME RES, JOHN F KENNEDY INST, GLOSTRUP, DENMARK

[8] OREGON HLTH SCI UNIV, DEPT MOLEC & MED GENET, PORTLAND, OR 97201 USA

[9] UNIV CATTOLICA SACRO CUORE, IST GENET MED, I-00168 ROME, ITALY

[10] UNIV INSTELLING ANTWERP, BORN BUNGE FDN, DEPT BIOCHEM, B-2610 WILRIJK, BELGIUM

来源：

GENOMICS | 1993年 / 16卷 / 03期

关键词：

D O I：

10.1006/geno.1993.1231

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

A genetic linkage map of human chromosome 21q (HC21q) containing 43 markers genotyped by the polymerase chain reaction in the CEPH pedigrees is presented. The markers placed on this map are highly polymorphic with an average heterozygosity of 61%. The average interval size of the markers localized at 1000:1 odds is 2.5 cM. The map has a total length of 65.5 cM, with male and female lengths of 47.7 and 83.3 cM, respectively. The genotypes used in the construction of this map were subjected to rigorous error checking, which is reflected in the shorter map length compared to previous maps; the estimated error rate in genotyping is less than 0.04%. As noted in previous linkage maps there is increased recombination in females on proximal HC 21q and in the male in a region near the telomere. This map of HC 21 represents a highly informative and dense meiotic linkage map and will be useful in linking disease phenotypes to loci on this chromosome. © 1993 Academic Press. All rights reserved.

引用

页码：562 / 571

页数：10

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