HTLV-I ASSOCIATED MYELOPATHY - CLINICOPATHOLOGICAL CORRELATION WITH LOCALIZATION OF PROVIRUS TO SPINAL-CORD

被引：51

作者：

BHIGJEE, AI

WILEY, CA

WACHSMAN, W

AMENOMORI, T

PIRIE, D

BILL, PLA

WINDSOR, I

机构：

[1] UNIV NATAL,DEPT ANAT PATHOL,PIETERMARITZBURG 3200,SOUTH AFRICA

[2] UNIV NATAL,DEPT VIROL,PIETERMARITZBURG 3200,SOUTH AFRICA

[3] UNIV CALIF SAN DIEGO,DEPT MED,DIV HEMATOL ONCOL,LA JOLLA,CA 92093

[4] UNIV CALIF SAN DIEGO,DEPT PATHOL,LA JOLLA,CA 92093

[5] UNIV CALIF SAN DIEGO,DEPT NEUROSCI,LA JOLLA,CA 92093

[6] VET ADM MED CTR,RES SERV,SAN DIEGO,CA 92161

[7] NAGASAKI UNIV,SCH MED,INST ATOM DIS,DEPT HEMATOL,NAGASAKI 852,JAPAN

来源：

NEUROLOGY | 1991年 / 41卷 / 12期

关键词：

D O I：

10.1212/WNL.41.12.1990

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

A 49-year-old South African man developed a rapidly progressive myelopathy 14 months after blood transfusion and died 1 year after the onset of symptoms. Detailed pathologic examination of the spinal cord was consistent with the diagnosis of HTLV-I-associated myelopathy/tropical spastic paraparesis (HAM/TSP). Although no HTLV-I viral particles, antigens, or nucleic acids were detected in situ, polymerase chain reaction assays revealed HTLV-I proviral DNA in cervical, thoracic, and lumbar levels of the spinal cord, with the greatest amount being detected at the thoracic level. These findings suggest that the pathogenesis of HAM/TSP depends on direct infection of neural or immune elements within the spinal cord.

引用

页码：1990 / 1992

页数：3

共 10 条

[1] MYELOPATHY ASSOCIATED WITH HUMAN T-CELL LYMPHOTROPIC VIRUS TYPE-I (HTLV-I) IN NATAL, SOUTH-AFRICA - A CLINICAL AND INVESTIGATIVE STUDY IN 24 PATIENTS [J].