METHOTREXATE FOR SYSTEMIC LUPUS-ERYTHEMATOSUS - A RETROSPECTIVE ANALYSIS OF 17 UNSELECTED CASES

被引：0
|
作者：
WILKE, WS [1 ]
KRALL, PL [1 ]
SCHEETZ, RJ [1 ]
BABIAK, T [1 ]
DANAO, T [1 ]
MAZANEC, DJ [1 ]
SEGAL, AM [1 ]
CLOUGH, JD [1 ]
机构：
[1] CLEVELAND CLIN FDN,DEPT RHEUMAT & IMMUNOL DIS,CLEVELAND,OH 44195
来源：
CLINICAL AND EXPERIMENTAL RHEUMATOLOGY | 1991年 / 9卷 / 06期
关键词：
METHOTREXATE; SYSTEMIC LUPUS ERYTHEMATOSUS; THERAPY; METHOTREXATE TOXICITY;
D O I：
暂无
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
We report a retrospective study of 17 patients with systemic lupus erythematosus who were treated with oral methotrexate given as a mean weekly dose of 8.47 +/- 1.72 mg. Methotrexate treatment resulted in symptomatic improvement in 57% of patients and allowed the reduction of the mean daily dose of prednisone from 16.66 mg initially to 8.99 mg at one year follow-up. Twelve of 17 patients (70.6%) experienced at least one episode of toxicity. Factors which might be associated with toxicity are analyzed. Because of its potential as a corticosteroid-sparing agent, controlled studies of methotrexate for the treatment of systemic lupus erythematosus are indicated.
引用
收藏
页码：581 / 587
页数：7
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