ENANTIOSELECTIVE TOTAL SYNTHESES OF BENGAMIDE-B AND BENGAMIDE-E

被引:55
作者
BROKA, CA
EHRLER, J
机构
[1] Syntex Research, Institute of Bio-Organic Chemistry, Palo Alto, CA 94304
关键词
D O I
10.1016/S0040-4039(00)79423-8
中图分类号
O62 [有机化学];
学科分类号
070303 ; 081704 ;
摘要
Convergent total syntheses of two sponge-derived cyclolysine derivatives - bengamides B (1) and E (2) - have been accomplished. The polyhydroxylated side chain common to both natural products was obtained from L-glucose and the hydroxylated caprolactam moiety of 1 was prepared using Evans' oxazolidinone chemistry. In the course of this work a new Horner-Emmons reagent incorporating one of Evans' chiral auxiliaries was developed.
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页码:5907 / 5910
页数:4
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