GERM-LINE TRANSMISSION OF A DISRUPTED BETA-2-MICROGLOBULIN GENE PRODUCED BY HOMOLOGOUS RECOMBINATION IN EMBRYONIC STEM-CELLS

被引：315
|
作者：
ZIJLSTRA, M
LI, E
SAJJADI, F
SUBRAMANI, S
JAENISCH, R
机构：
[1] UNIV CALIF SAN DIEGO, DEPT BIOL, LA JOLLA, CA 92093 USA
[2] MIT, DEPT BIOL, CAMBRIDGE, MA 02139 USA
来源：
NATURE | 1989年 / 342卷 / 6248期
关键词：
D O I：
10.1038/342435a0
中图分类号：
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
引用
收藏
页码：435 / 438
页数：4
相关论文
共 50 条
  • [41] Efficient germ-line transmission obtained with transgene-free induced pluripotent stem cells
    Wu, Sen
    Wu, Yuanyuan
    Zhang, Xi
    Capecchi, Mario R.
    PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2014, 111 (29) : 10678 - 10683
  • [42] DOUBLE REPLACEMENT - STRATEGY FOR EFFICIENT INTRODUCTION OF SUBTLE MUTATIONS INTO THE MURINE COL1A-1 GENE BY HOMOLOGOUS RECOMBINATION IN EMBRYONIC STEM-CELLS
    WU, H
    LIU, X
    JAENISCH, R
    PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1994, 91 (07) : 2819 - 2823
  • [43] Production of p53 gene knockout rats by homologous recombination in embryonic stem cells
    Tong, Chang
    Li, Ping
    Wu, Nancy L.
    Yan, Youzhen
    Ying, Qi-Long
    NATURE, 2010, 467 (7312) : 211 - U98
  • [44] Production of p53 gene knockout rats by homologous recombination in embryonic stem cells
    Chang Tong
    Ping Li
    Nancy L. Wu
    Youzhen Yan
    Qi-Long Ying
    Nature, 2010, 467 : 211 - 213
  • [45] Targeting of the homeobox gene, mixl1, by homologous recombination in human embryonic stem cells
    Davis, R.
    Costa, M.
    Sourris, K.
    Elefanty, A.
    Stanley, E.
    MECHANISMS OF DEVELOPMENT, 2005, 122 : S170 - S170
  • [46] MOUSE EMBRYONIC STEM-CELLS EXHIBIT HIGH-LEVELS OF EXTRACHROMOSOMAL HOMOLOGOUS RECOMBINATION IN A CHLORAMPHENICOL ACETYLTRANSFERASE ASSAY SYSTEM
    JASIN, M
    LIANG, F
    NUCLEIC ACIDS RESEARCH, 1991, 19 (25) : 7171 - 7175
  • [47] HOMOLOGOUS RECOMBINATION AT C-FYN LOCUS OF MOUSE EMBRYONIC STEM-CELLS WITH USE OF DIPHTHERIA-TOXIN A-FRAGMENT GENE IN NEGATIVE SELECTION
    YAGI, T
    IKAWA, Y
    YOSHIDA, K
    SHIGETANI, Y
    TAKEDA, N
    MABUCHI, I
    YAMAMOTO, T
    AIZAWA, S
    PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1990, 87 (24) : 9918 - 9922
  • [48] Generating Hypoimmunogenic Human Embryonic Stem Cells by the Disruption of Beta 2-Microglobulin
    Pengfei Lu
    Jijun Chen
    Lixiazi He
    Jiangtao Ren
    Haide Chen
    Lingjun Rao
    Qinggang Zhuang
    Hui Li
    Lei Li
    Lei Bao
    Ji He
    Wei Zhang
    Faming Zhu
    Chun Cui
    Lei Xiao
    Stem Cell Reviews and Reports, 2013, 9 : 806 - 813
  • [49] Generating Hypoimmunogenic Human Embryonic Stem Cells by the Disruption of Beta 2-Microglobulin
    Lu, Pengfei
    Chen, Jijun
    He, Lixiazi
    Ren, Jiangtao
    Chen, Haide
    Rao, Lingjun
    Zhuang, Qinggang
    Li, Hui
    Li, Lei
    Bao, Lei
    He, Ji
    Zhang, Wei
    Zhu, Faming
    Cui, Chun
    Xiao, Lei
    STEM CELL REVIEWS AND REPORTS, 2013, 9 (06) : 806 - 813
  • [50] GENERATION OF CHIMERIC MICE WITH GLUCOCEREBROSIDASE GENE-MUTATIONS INTRODUCED BY TARGETED HOMOLOGOUS RECOMBINATION IN EMBRYONIC STEM-CELLS TO PRODUCE A MOUSE MODEL OF GAUCHER DISEASE
    TYBULEWICZ, V
    TREMBLAY, ML
    LAMARCA, ME
    STUBBLEFIELD, BK
    WINFIELD, S
    ZABLOCKA, B
    SIDRANSKY, E
    MARTIN, BM
    WESTPHAL, H
    MULLIGAN, RC
    GINNS, EI
    AMERICAN JOURNAL OF HUMAN GENETICS, 1991, 49 (04) : 441 - 441
12345