TUMOR PROMOTERS INDUCE MEMBRANE CHANGES DETECTED BY FLUORESCENCE POLARIZATION

被引：75

作者：

FISHER, PB

FLAMM, M

SCHACHTER, D

WEINSTEIN, IB

机构：

[1] COLUMBIA UNIV,COLL PHYS & SURG,INST CANC RES,DEPT MED,NEW YORK,NY 10032

[2] COLUMBIA UNIV,COLL PHYS & SURG,DIV ENVIRONM SCI,NEW YORK,NY 10032

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 1979年 / 86卷 / 04期

基金：

美国国家卫生研究院;

关键词：

D O I：

10.1016/0006-291X(79)90225-0

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The probe, 1,6-diphenyl-1,3,5-hexatriene (DPH) was used to determine if tumor promoting agents alter cell membranes. The active tumor promoters TPA (12-0-tetra-decanoyl-phorbol-13-acetate), PDD (phorbol-12,13-didecanoate) and PDB (phorbol-12,13-dibenzoate) were found to decrease fluorescence polarization of DPH in rat embryo cells, whereas the inactive tumor promoting compounds phorbol and 4α-PDD failed to induce this change. © 1979.

引用

页码：1063 / 1068

页数：6

共 27 条

[1]

BERENBLUM I, 1975, CANCER COMPREHENSIVE, V1, P323

[2] EFFECT OF A PHORBOL ESTER ON A TRANSFORMATION-SENSITIVE SURFACE PROTEIN OF CHICK FIBROBLASTS [J].