SYNTHESIS AND ANTIBACTERIAL ACTIVITY OF C-2 ALKENYLTHIO-CARBAPENEM DERIVATIVES

被引：0
|
作者：
CORBETT, DF [1 ]
COULTON, S [1 ]
KNOWLES, DJ [1 ]
SOUTHGATE, R [1 ]
机构：
[1] BEECHAM PHARMACEUT,BROCKHAM PK,BETCHWORTH RH3 7AJ,SURREY,ENGLAND
来源：
JOURNAL OF ANTIBIOTICS | 1990年 / 43卷 / 09期
关键词：
D O I：
10.7164/antibiotics.43.1137
中图分类号：
Q81 [生物工程学（生物技术）]; Q93 [微生物学];
学科分类号：
071005 ; 0836 ; 090102 ; 100705 ;
摘要：
A number of C-2 aminoalkenylthio-carbapenem derivatives possessing both the (5R, 6R, 8S)- and the (5R, 6S, 8R)-stereochemistries have been prepared from the olivanic acids MM 22382 and MM 22383, respectively. Certain members of this new class of compounds displayed potent, broad spectrum antibacterial activity as well as improved stability to human kidney homogenate. © 1990, JAPAN ANTIBIOTICS RESEARCH ASSOCIATION. All rights reserved.
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页码：1137 / 1149
页数：13
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