SYNTHESIS AND ANTIBACTERIAL ACTIVITY OF C-2 ALKENYLTHIO-CARBAPENEM DERIVATIVES

被引：0

作者：

CORBETT, DF ^{[1
]}

COULTON, S ^{[1
]}

KNOWLES, DJ ^{[1
]}

SOUTHGATE, R ^{[1
]}

机构：

[1] BEECHAM PHARMACEUT,BROCKHAM PK,BETCHWORTH RH3 7AJ,SURREY,ENGLAND

来源：

JOURNAL OF ANTIBIOTICS | 1990年 / 43卷 / 09期

关键词：

D O I：

10.7164/antibiotics.43.1137

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

A number of C-2 aminoalkenylthio-carbapenem derivatives possessing both the (5R, 6R, 8S)- and the (5R, 6S, 8R)-stereochemistries have been prepared from the olivanic acids MM 22382 and MM 22383, respectively. Certain members of this new class of compounds displayed potent, broad spectrum antibacterial activity as well as improved stability to human kidney homogenate. © 1990, JAPAN ANTIBIOTICS RESEARCH ASSOCIATION. All rights reserved.

引用

页码：1137 / 1149

页数：13

共 15 条

[1] SYNTHESIS AND ANTIBACTERIAL ACTIVITY OF C-2 CARBOXYETHENYLTHIO-CARBAPENEM DERIVATIVES [J].

BASKER, MJ ;

CORBETT, DF ;

COULTON, S ;

SOUTHGATE, R .

JOURNAL OF ANTIBIOTICS, 1990, 43 (07) :847-857

[2] 4 FURTHER ANTIBIOTICS RELATED TO OLIVANIC ACID PRODUCED BY STREPTOMYCES-OLIVACEUS - FERMENTATION, ISOLATION, CHARACTERIZATION AND BIOSYNTHETIC-STUDIES [J].

BOX, SJ ;

HOOD, JD ;

SPEAR, SR .

JOURNAL OF ANTIBIOTICS, 1979, 32 (12) :1239-1247

[3] BETA-LACTAM NOMENCLATURE [J].

BROWN, AG .

JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY, 1982, 10 (05) :365-368

[4] INVERSION OF CONFIGURATION AT C-8 IN THE OLIVANIC ACIDS - CONVERSION INTO THE THIENAMYCINS AND OTHER NOVEL DERIVATIVES [J].

CORBETT, DF ;

COULTON, S ;

SOUTHGATE, R .

JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 1, 1982, (12) :3011-3016

[5] REACTION OF OLIVANIC ACIDS WITH HYPOBROMOUS ACID - THE PREPARATION AND USE OF A VERSATILE INTERMEDIATE, THE C-3 THIOL [J].

CORBETT, DF .

JOURNAL OF THE CHEMICAL SOCIETY-CHEMICAL COMMUNICATIONS, 1981, (15) :803-805

[6]

CORBETT DF, 1979, Patent No. 8885

[7] BETA-THIOXO ESTERS .2. EVIDENCE FOR ESTER GROUP ROTAMERISM AND PERTURBATION OF INTRAMOLECULAR HYDROGEN-BONDING IN ENETHIOLIZED 2-THIOXO CYCLOALKANECARBOXYLIC ESTERS [J].

DUUS, F .

TETRAHEDRON, 1974, 30 (20) :3753-3763

[8] OLIVANIC ACIDS, A FAMILY OF BETA-LACTAM ANTIBIOTICS WITH BETA-LACTAMASE INHIBITORY PROPERTIES PRODUCED BY STREPTOMYCES SPECIES .2. ISOLATION AND CHARACTERIZATION OF THE OLIVANIC ACIDS MM-4550, MM-13902 AND MM-17880 FROM STREPTOMYCES-OLIVACEUS [J].

HOOD, JD ;

BOX, SJ ;

VERRALL, MS .

JOURNAL OF ANTIBIOTICS, 1979, 32 (04) :295-304

[9] INVITRO ACTIVITY OF N-FORMIMIDOYL THIENAMYCIN (MK0787), A CRYSTALLINE DERIVATIVE OF THIENAMYCIN [J].

HORADAM, VW ;

SMILACK, JD ;

MONTGOMERY, CL ;

WERRINGLOER, J .

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 1980, 18 (04) :557-561

[10]

JACKMAN LM, 1969, INT SERIES MONOGRAPH, V5, P184

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