Platelet Aggregation In Patients With Arterial Hypertension With Abdominal Obesity And Dyslipidemia

Unfortunately, among the population of many countries the number of suffering simultaneously arterial hypertension, abdominal obesity and dyslipidemia increases. It was revealed that they are characterized by a high incidence of thrombosis. This is due to the presence of their thrombocytopathy, the characteristics of which have not yet been fully investigated. The goal is to clarify the features of aggregation properties of platelets in patients with arterial hypertension with abdominal obesity and dyslipidemia. We examined 47 patients of the second adult age (mean age 53.4 +/- 2.5 years) with grade 1 arterial hypertension, risk 4 with abdominal obesity and dyslipidemia. The control group consisted of 26 clinically healthy people of the same age. All the examined persons gave written informed consent to participate in the study. Biochemical, hematological and statistical methods of investigation were used in the work. The high frequency of thromboses of various localizations peculiar to this patient population is in many respects closely related to the development of platelet hyperaggregation in them. This violation occurs largely due to the weakening of the antioxidant protection of the plasma with the activation of the processes of lipid peroxidation in it. Also, in individuals with hypertension and abdominal obesity and dyslipidemia, weakened platelet disaggregation. As a result, patients receive a sharply increased risk of thrombosis of any location, which can lead to disability and death.