EFFECT OF SC-15396, ATROPINE AND MEPYRAMINE ON GASTRIN-, BETHANECHOL- AND HISTAMINE-STIMULATED GASTRIC ACID SECRETION IN RATS AND GUINEA-PIGS

被引：14

作者：

ALBINUS, M

SEWING, KF

机构：

[1] Department of Pharmacology, University of Tübingen, West Germany

来源：

JOURNAL OF PHARMACY AND PHARMACOLOGY | 1969年 / 21卷 / 10期

关键词：

D O I：

10.1111/j.2042-7158.1969.tb08141.x

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The effect of SC‐15396 (“antigastrin”; 2‐phenyl‐2‐(2‐pyridyl)thioacetamide), atropine and mepyramine on gastrin‐, bethanechol‐ and histamine‐stimulated gastric acid secretion was studied in rats and guinea‐pigs. For all three stimulants parallel dose response curves were obtained except in guinea‐pigs where bethanechol even in very high doses displays a poor activity in stimulating gastric acid secretion. The maximal secretory response was found to be 12·7 ± 5·0 μ‐equiv HCl/10 min in rats and 53·2 ± 27£9 μ‐equiv HCl/10 min in guinea‐pigs. All stimulating effects on gastric acid secretion were reduced by SC‐15396; atropine abolished the secretory responses to bethanechol. Mepyramine was ineffective. In accordance with these findings the mechanism of action of gastrin and a receptor model on the oxyntic cell are discussed. 1969 Royal Pharmaceutical Society of Great Britain

引用

页码：656 / &

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