PREPARATION AND STABILITY OF DL-ALPHA-TOCOPHEROL LABELLED WITH TRITIUM AT HIGH SPECIFIC ACTIVITY

被引：3
|
作者：
EVANS, EA
PHILLIPS, RF
机构：
[1] The Radiochemical Centre, Amersham, Buckinghamshire
来源：
JOURNAL OF LABELLED COMPOUNDS | 1969年 / 5卷 / 01期
关键词：
D O I：
10.1002/jlcr.2590050104
中图分类号：
O65 [分析化学];
学科分类号：
070302 ; 081704 ;
摘要：
Hydrogen‐tritium exchange labelling methods proved to be unsatisfactory for the preparation of tritiated DL‐α‐tocopherol at high specific activity. The preparation of α‐tocopherol specifically labelled in the 5‐methyl hydrogen positions is described : the method permits specific activities in the curies per millimole range to be readily achieved. The synthesis is also suitable for preparing tocopherol doubly labelled with tritium and carbon‐14. The stability of the tritiated vitamin on storage is discussed. Copyright © 1969 John Wiley & Sons, Ltd.
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