STRUCTURE AND CHROMOSOMAL LOCALIZATION OF A HUMAN WATER CHANNEL (AQP3) GENE

被引：68
作者：
ISHIBASHI, K
SASAKI, S
SAITO, F
IKEUCHI, T
MARUMO, F
机构：
[1] TOKYO MED & DENT UNIV,MED RES INST,DEPT CYTOGENET,BUNKYO KU,TOKYO 113,JAPAN
[2] OUME GEN HOSP,RENAL UNIT,TOKYO 198,JAPAN
来源：
GENOMICS | 1995年 / 27卷 / 02期
关键词：
D O I：
10.1006/geno.1995.1055
中图分类号：
Q81 [生物工程学（生物技术）]; Q93 [微生物学];
学科分类号：
071005 ; 0836 ; 090102 ; 100705 ;
摘要：
A cDNA encoding rat AQP3, a water channel and a member of the MIP family, that is expressed predominantly in kidney medulla and colon was cloned recently. To determine the structure, tissue distribution, and chromosomal localization of the human AQP3 gene, we screened a human kidney cDNA library with rat AQP3 probe and isolated a cDNA coding for human AQP3 protein. The deduced amino acid sequence of human AQP3 was 98% identical to rat AQP3. Human AQP3 mRNA was expressed in colon, kidney, liver, pancreas, lung, peripheral leukocytes, spleen, and prostate. The human AQP3 gene was mapped to 7q36.2-q36.3 by chromosome fluorescence in situ hybridization. (C) 1995 Academic Press, Inc.
引用
收藏
页码：352 / 354
页数：3
相关论文
共 9 条
[1]   AQUAPORINS - A FAMILY OF WATER CHANNEL PROTEINS [J].
AGRE, P ;
SASAKI, S ;
CHRISPEELS, MJ .
AMERICAN JOURNAL OF PHYSIOLOGY, 1993, 265 (03) :F461-F461
[2]   ASSIGNMENT OF THE HUMAN GENE FOR THE WATER CHANNEL OF RENAL COLLECTING DUCT AQUAPORIN-2 (AQP2) TO CHROMOSOME-12 REGION Q12-]Q13 [J].
DEEN, PMT ;
WEGHUIS, DO ;
SINKE, RJ ;
VANKESSEL, AG ;
WIERINGA, B ;
VANOS, CH .
CYTOGENETICS AND CELL GENETICS, 1994, 66 (04) :260-262
[3]   MOLECULAR-CLONING AND EXPRESSION OF A MEMBER OF THE AQUAPORIN FAMILY WITH PERMEABILITY TO GLYCEROL AND UREA IN ADDITION TO WATER EXPRESSED AT THE BASOLATERAL MEMBRANE OF KIDNEY COLLECTING DUCT CELLS [J].
ISHIBASHI, K ;
SASAKI, S ;
FUSHIMI, K ;
UCHIDA, S ;
KUWAHARA, M ;
SAITO, H ;
FURUKAWA, T ;
NAKAJIMA, K ;
YAMAGUCHI, Y ;
GOJOBORI, T ;
MARUMO, F .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1994, 91 (14) :6269-6273
[4]  
MOON C, 1993, J BIOL CHEM, V268, P15772
[5]   THE MIP FAMILY OF INTEGRAL MEMBRANE CHANNEL PROTEINS - SEQUENCE COMPARISONS, EVOLUTIONARY RELATIONSHIPS, RECONSTRUCTED PATHWAY OF EVOLUTION, AND PROPOSED FUNCTIONAL-DIFFERENTIATION OF THE 2 REPEATED HALVES OF THE PROTEINS [J].
REIZER, J ;
REIZER, A ;
SAIER, MH .
CRITICAL REVIEWS IN BIOCHEMISTRY AND MOLECULAR BIOLOGY, 1993, 28 (03) :235-257
[6]   HUMAN AQP2 AND MIP GENES, 2 MEMBERS OF THE MIP FAMILY, MAP WITHIN CHROMOSOME BAND-12Q13 ON THE BASIS OF 2-COLOR FISH [J].
SAITO, F ;
SASAKI, S ;
CHEPELINSKY, AB ;
FUSHIMI, K ;
MARUMO, F ;
IKEUCHI, T .
CYTOGENETICS AND CELL GENETICS, 1995, 68 (1-2) :45-48
[7]   CLONING, CHARACTERIZATION, AND CHROMOSOMAL MAPPING OF HUMAN AQUAPORIN OF COLLECTING DUCT [J].
SASAKI, S ;
FUSHIMI, K ;
SAITO, H ;
SAITO, F ;
UCHIDA, S ;
ISHIBASHI, K ;
KUWAHARA, M ;
IKEUCHI, T ;
INUI, K ;
NAKAJIMA, K ;
WATANABE, TX ;
MARUMO, F .
JOURNAL OF CLINICAL INVESTIGATION, 1994, 93 (03) :1250-1256
[8]  
SASAKI S, 1995, IN PRESS KIDNEY INT
[9]   A HIGH-RESOLUTION CYTOGENETIC MAP OF HUMAN CHROMOSOME-3 - LOCALIZATION OF 291 NEW COSMID MARKERS BY DIRECT R-BANDING FLUORESCENCE INSITU HYBRIDIZATION [J].
TAKAHASHI, E ;
YAMAKAWA, K ;
NAKAMURA, Y ;
HORI, T .
GENOMICS, 1992, 13 (04) :1047-1055
1