STRUCTURE AND CHROMOSOMAL LOCALIZATION OF A HUMAN WATER CHANNEL (AQP3) GENE

被引:68
作者
ISHIBASHI, K
SASAKI, S
SAITO, F
IKEUCHI, T
MARUMO, F
机构
[1] TOKYO MED & DENT UNIV,MED RES INST,DEPT CYTOGENET,BUNKYO KU,TOKYO 113,JAPAN
[2] OUME GEN HOSP,RENAL UNIT,TOKYO 198,JAPAN
关键词
D O I
10.1006/geno.1995.1055
中图分类号
Q81 [生物工程学(生物技术)]; Q93 [微生物学];
学科分类号
071005 ; 0836 ; 090102 ; 100705 ;
摘要
A cDNA encoding rat AQP3, a water channel and a member of the MIP family, that is expressed predominantly in kidney medulla and colon was cloned recently. To determine the structure, tissue distribution, and chromosomal localization of the human AQP3 gene, we screened a human kidney cDNA library with rat AQP3 probe and isolated a cDNA coding for human AQP3 protein. The deduced amino acid sequence of human AQP3 was 98% identical to rat AQP3. Human AQP3 mRNA was expressed in colon, kidney, liver, pancreas, lung, peripheral leukocytes, spleen, and prostate. The human AQP3 gene was mapped to 7q36.2-q36.3 by chromosome fluorescence in situ hybridization. (C) 1995 Academic Press, Inc.
引用
收藏
页码:352 / 354
页数:3
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