DETERMINATION OF HYDROPHILE-LIPOPHILE BALANCE OF SOME POLYETHOXYLATED NONIONIC SURFACTANTS BY REVERSED-PHASE THIN-LAYER CHROMATOGRAPHY

被引：16
作者：
TRAPANI, G
ALTOMARE, C
FRANCO, M
LATROFA, A
LISO, G
机构：
[1] Dipartimento Farmaco-Chimico, Università degli Studi di Bari, 70125 Bari
来源：
INTERNATIONAL JOURNAL OF PHARMACEUTICS | 1995年 / 116卷 / 01期
关键词：
HYDROPHILE LIPOPHILE BALANCE; RP-TLC; NONIONIC SURFACTANT;
D O I：
10.1016/0378-5173(94)00279-E
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
A study has been carried out to verify the applicability of RP-TLC to the determination of the HLB values of some polyethoxylated non-ionic surfactants. Our results show that adsorption phenomena do not significantly affect retention and that a linear relation exists between the HLB value and the lipophilicity parameter R(Mo). A deviation from this linear correlation was observed for compounds bearing hydrophilic chains with more than 12-13 ethylene oxide units. These exceptions can be explained in terms of methodological limitations and/or conformational properties. RP-TLC method appears to be a simple, rapid and inexpensive way to rank non-ionic amphiphilic substances.
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页码：95 / 99
页数：5
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