STEREOSELECTIVE ANTAGONISM OF PHENCYCLIDINES DISCRIMINATIVE PROPERTIES BY ADENOSINE RECEPTOR AGONISTS

被引：64
作者：
BROWNE, RG [1 ]
WELCH, WM [1 ]
机构：
[1] PFIZER INC, CENT RES, DEPT CHEM, GROTON, CT 06340 USA
来源：
SCIENCE | 1982年 / 217卷 / 4565期
关键词：
D O I：
10.1126/science.6287578
中图分类号：
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
Rats trained to discriminate between phencyclidine [PCP] and saline vehicle were used to test various agents for their ability to mimic or block the PCP cue. Ketamine, dexoxadrol, tiletamine and PCP analogs mimicked behavioral effects of PCP. Treatment with the adenosine receptor agonists, N6-cyclohexyladenosine and L-phenylisopropyladenosine, blocked the discriminative properties of PCP. Adenosine receptor agonists might be useful in treating [human] PCP-induced psychosis.
引用
收藏
页码：1157 / 1159
页数：3
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