STEREOSELECTIVE ANTAGONISM OF PHENCYCLIDINES DISCRIMINATIVE PROPERTIES BY ADENOSINE RECEPTOR AGONISTS

被引：64
作者：
BROWNE, RG [1 ]
WELCH, WM [1 ]
机构：
[1] PFIZER INC, CENT RES, DEPT CHEM, GROTON, CT 06340 USA
来源：
SCIENCE | 1982年 / 217卷 / 4565期
关键词：
D O I：
10.1126/science.6287578
中图分类号：
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
Rats trained to discriminate between phencyclidine [PCP] and saline vehicle were used to test various agents for their ability to mimic or block the PCP cue. Ketamine, dexoxadrol, tiletamine and PCP analogs mimicked behavioral effects of PCP. Treatment with the adenosine receptor agonists, N6-cyclohexyladenosine and L-phenylisopropyladenosine, blocked the discriminative properties of PCP. Adenosine receptor agonists might be useful in treating [human] PCP-induced psychosis.
引用
收藏
页码：1157 / 1159
页数：3
相关论文
共 41 条
  • [11] INHIBITION OF ACETYLCHOLINE-RELEASE IN GUINEA-PIG ILEUM BY ADENOSINE
    GUSTAFSSON, L
    HEDQVIST, P
    FREDHOLM, BB
    LUNDGREN, G
    [J]. ACTA PHYSIOLOGICA SCANDINAVICA, 1978, 104 (04): : 469 - 478
  • [12] THEOPHYLLINE INTERFERES WITH THE MODULATORY ROLE OF ENDOGENOUS ADENOSINE ON CHOLINERGIC NEUROTRANSMISSION IN GUINEA-PIG ILEUM
    GUSTAFSSON, L
    FREDHOLM, BB
    HEDQVIST, P
    [J]. ACTA PHYSIOLOGICA SCANDINAVICA, 1981, 111 (03): : 269 - 280
  • [13] EFFECTS OF PURINE COMPOUNDS ON CHOLINERGIC NERVES - SPECIFICITY OF ADENOSINE AND RELATED COMPOUNDS ON ACETYLCHOLINE-RELEASE IN ELECTRICALLY STIMULATED GUINEA-PIG ILEUM
    HAYASHI, E
    MORI, M
    YAMADA, S
    KUNITOMO, M
    [J]. EUROPEAN JOURNAL OF PHARMACOLOGY, 1978, 48 (03) : 297 - 307
  • [14] EFFECTS OF ADENOSINE ON ADRENERGIC NEUROTRANSMISSION - PREJUNCTIONAL INHIBITION AND POSTJUNCTIONAL ENHANCEMENT
    HEDQVIST, P
    FREDHOLM, BB
    [J]. NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY, 1976, 293 (03) : 217 - 223
  • [15] HOLTZMAN SG, 1980, J PHARMACOL EXP THER, V214, P614
  • [16] DRUG DISCRIMINATION IN RATS - EFFECTS OF PHENCYCLIDINE AND DITRAN
    JARBE, TUC
    JOHANSSON, JO
    HENRIKSSON, BG
    [J]. PSYCHOPHARMACOLOGIA, 1975, 42 (01): : 33 - 39
  • [17] SPECIFIC BINDING OF [PHENCYCLIDINES-H-3 TO MEMBRANE PREPARATION - POSSIBLE INTERACTION WITH THE CHOLINERGIC IONOPHORE
    KLOOG, Y
    KALIR, A
    BUCHMAN, O
    SOKOLOVSKY, M
    [J]. FEBS LETTERS, 1980, 109 (01): : 125 - 128
  • [18] LASAGNA L, 1965, P SOC EXP BIOL MED, V118, P352
  • [19] STUDY OF A NEW SCHIZOPHRENOMIMETIC DRUG - SERNYL
    LUBY, ED
    COHEN, BD
    ROSENBAUM, G
    GOTTLIEB, JS
    KELLEY, R
    [J]. ARCHIVES OF NEUROLOGY AND PSYCHIATRY, 1959, 81 (03): : 363 - 369
  • [20] Luisada P V, 1978, NIDA Res Monogr, P241
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