ASSOCIATION AND ACTIVATION OF JAK-TYK KINASES BY CNTF-LIF-OSM-IL-6 BETA-RECEPTOR COMPONENTS

被引：933
作者：
STAHL, N
BOULTON, TG
FARRUGGELLA, T
IP, NY
DAVIS, S
WITTHUHN, BA
QUELLE, FW
SILVENNOINEN, O
BARBIERI, G
PELLEGRINI, S
IHLE, JN
YANCOPOULOS, GD
机构：
[1] ST JUDE CHILDRENS RES HOSP, DEPT BIOCHEM, MEMPHIS, TN 38105 USA
[2] INST PASTEUR, INSERM, U276, F-75724 PARIS 15, FRANCE
来源：
SCIENCE | 1994年 / 263卷 / 5143期
关键词：
D O I：
10.1126/science.8272873
中图分类号：
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
A recently defined family of cytokines, consisting of ciliary neurotrophic factor (CNTF), leukemia inhibitory factor (LIF), oncostatin M (OSM), and interleukin-6 (IL-6), utilize the Jak-Tyk family of cytoplasmic tyrosine kinases. The beta receptor components for this cytokine family, gp130 and LIF receptor beta, constitutively associate with Jak-Tyk kinases. Activation of these kinases occurs as a result of ligand-induced dimerization of the receptor beta components. Unlike other cytokine receptors studied to date, the receptors for the CNTF cytokine family utilize all known members of the Jak-Tyk family, but induce distinct patterns of Jak-Tyk phosphorylation in different cell lines.
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收藏
页码：92 / 95
页数：4
相关论文
共 33 条
[1]   IDENTIFICATION OF JAK2 AS A GROWTH-HORMONE RECEPTOR-ASSOCIATED TYROSINE KINASE [J].
ARGETSINGER, LS ;
CAMPBELL, GS ;
YANG, XN ;
WITTHUHN, BA ;
SILVENNOINEN, O ;
IHLE, JN ;
CARTERSU, C .
CELL, 1993, 74 (02) :237-244
[2]  
BAUMANN H, 1993, J BIOL CHEM, V268, P8414
[3]   NEUROPOIETIC CYTOKINES IN THE HEMATOPOIETIC FOLD [J].
BAZAN, JF .
NEURON, 1991, 7 (02) :197-208
[4]   MOLECULAR ASSOCIATIONS BETWEEN THE LYMPHOCYTE-T ANTIGEN RECEPTOR COMPLEX AND THE SURFACE ANTIGEN-CD2, ANTIGEN-CD4, OR ANTIGEN-CD8 AND ANTIGEN-CD5 [J].
BEYERS, AD ;
SPRUYT, LL ;
WILLIAMS, AF .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1992, 89 (07) :2945-2949
[5]  
BOLEN JB, 1993, ONCOGENE, V8, P2025
[6]   LIFR-BETA AND GP-130 AS HETERODIMERIZING SIGNAL TRANSDUCERS OF THE TRIPARTITE CNTF RECEPTOR [J].
DAVIS, S ;
ALDRICH, TH ;
STAHL, N ;
PAN, L ;
TAGA, T ;
KISHIMOTO, T ;
IP, NY ;
YANCOPOULOS, GD .
SCIENCE, 1993, 260 (5115) :1805-1808
[7]   RELEASED FORM OF CNTF RECEPTOR-ALPHA COMPONENT AS A SOLUBLE MEDIATOR OF CNTF RESPONSES [J].
DAVIS, S ;
ALDRICH, TH ;
IP, NY ;
STAHL, N ;
SCHERER, S ;
FARRUGGELLA, T ;
DISTEFANO, PS ;
CURTIS, R ;
PANAYOTATOS, N ;
GASCAN, H ;
CHEVALIER, S ;
YANCOPOULOS, GD .
SCIENCE, 1993, 259 (5102) :1736-1739
[8]   THE RECEPTOR FOR CILIARY NEUROTROPHIC FACTOR [J].
DAVIS, S ;
ALDRICH, TH ;
VALENZUELA, DM ;
WONG, V ;
FURTH, ME ;
SQUINTO, SP ;
YANCOPOULOS, GD .
SCIENCE, 1991, 253 (5015) :59-63
[9]  
EISEMAN E, 1992, NATURE, V355, P78
[10]   ISOLATION OF MONOCLONAL-ANTIBODIES SPECIFIC FOR HUMAN C-MYC PROTO-ONCOGENE PRODUCT [J].
EVAN, GI ;
LEWIS, GK ;
RAMSAY, G ;
BISHOP, JM .
MOLECULAR AND CELLULAR BIOLOGY, 1985, 5 (12) :3610-3616
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