SARS-CoV-2 vaccination and risk of severe COVID-19 outcomes in patients with autoimmune hepatitis

被引：0

作者：

Efe, Cumali ^{[1
]}

Tascilar, Koray ^{[2
,3
]}

Gerussi, Alessio ^{[4
,5
,6
]}

Bolis, Francesca ^{[4
,5
]}

Lammert, Craig ^{[7
]}

Ebik, Berat ^{[8
]}

Stattermayer, Albert Friedrich ^{[9
]}

Cengiz, Mustafa ^{[10
]}

Gokce, Dilara Turan ^{[11
]}

Cristoferi, Laura ^{[4
,5
,6
]}

Peralta, Mirta ^{[12
,13
]}

Massoumi, Hatef ^{[14
]}

Montes, Pedro ^{[15
]}

Cerda, Eira ^{[16
]}

Rigamonti, Cristina ^{[17
,18
]}

Yapali, Suna ^{[19
]}

Adali, Gupse ^{[20
]}

Caliskan, Ali Riza ^{[21
]}

Balaban, Yasemin ^{[22
]}

Eren, Fatih ^{[23
]}

Eskazan, Tugce ^{[24
]}

Barutcu, Sezgin ^{[25
]}

Lytvyak, Ellina ^{[26
,27
]}

Zazueta, Godolfino Miranda ^{[28
]}

Kayhan, Meral Akdogan ^{[10
]}

Heurgue-Berlot, Alexandra ^{[29
]}

De Martin, Eleonora ^{[30
]}

Yavuz, Ahmet ^{[31
]}

Biyik, Murat ^{[31
]}

Narro, Graciela Castro ^{[28
]}

Duman, Serkan ^{[32
]}

Hernandez, Nelia ^{[33
]}

Gatselis, Nikolaos K. ^{[34
,35
,36
]}

Aguirre, Jonathan ^{[37
]}

Idilman, Ramazan ^{[32
]}

Silva, Marcelo ^{[13
,38
]}

Mendizabal, Manuel ^{[13
,38
]}

Atay, Kadri ^{[39
]}

Guzelbulut, Fatih ^{[40
]}

Dhanasekaran, Renumathy ^{[41
]}

Montano-Loza, Aldo J. ^{[26
,27
]}

Dalekos, George N. ^{[34
,35
,36
]}

Ridruejo, Ezequiel ^{[13
,38
,42
]}

Invernizzi, Pietro ^{[4
,5
,6
]}

Wahlin, Staffan ^{[43
,44
]}

机构：

[1] Harran Univ Hosp, Dept Gastroenterol, Sanliurfa, Turkey

[2] Friedrich Alexander Univ FAU Erlangen Nurnberg, Dept Med Rheumatol & Immunol 3, Erlangen, Germany

[3] Univ Klinikum Erlangen, Erlangen, Germany

[4] Univ Milano Bicocca, Div Gastroenterol, Dept Med & Surg, Monza, Italy

[5] Univ Milano Bicocca, Ctr Autoimmune Liver Dis, Dept Med & Surg, Monza, Italy

[6] San Gerardo Hosp, European Reference Network Hepatol Dis ERN RARE L, Monza, Italy

[7] Univ Sch Med, Dept Med Indiana, Indianapolis, IN USA

[8] Gazi Yasargil Educ & Res Hosp, Dept Gastroenterol, Diyarbakir, Turkey

[9] Med Univ Vienna, Dept Internal Med 3, Div Gastroenterol & Hepatol, Vienna, Austria

[10] Gulhane Training & Res Hosp, Dept Gastroenterol, Ankara, Turkey

[11] Ankara City Hosp, Dept Gastroenterol, Ankara, Turkey

[12] Hosp Francisco J Muniz, Hepatol Sect, Buenos Aires, DF, Argentina

[13] Latin Amer Liver Res Educ & Awareness Network LAL, Pilar, Argentina

[14] Montefiore Med Ctr, Dept Med, Bronx, NY 10467 USA

[15] Hosp Nacl Daniel A Carrion, Gastroenterol & Hepatol Unit, Callao, Peru

[16] Hosp Mil Cent Mexico, Hepatol Unit, Ciudad De Mexico, Mexico

[17] Univ Piemonte Orientale UPO, Dept Translat Med, Novara, Italy

[18] AOU Maggiore della Carita, Div Internal Med, Novara, Italy

[19] Acibadem Univ, Dept Gastroenterol, Sch Med, Istanbul, Turkey

[20] Umraniye Educ & Res Hosp, Dept Gastroenterol, Istanbul, Turkey

[21] Adiyaman Univ, Dept Gastroenterol, Adiyaman, Turkey

[22] Hacettepe Univ, Fac Med, Dept Gastroenterol, Ankara, Turkey

[23] Uludag Univ, Med Fac, Dept Gastroenterol, Bursa, Turkey

[24] Cerrahpa Sch Med, Dept Gastroenterol, Istanbul, Turkey

[25] Univ Gaziantep Med Fac, Dept Gastroenterol, Gaziantep, Turkey

[26] Univ Alberta, Div Gastroenterol, Edmonton, AB, Canada

[27] Univ Alberta, Liver Unit, Edmonton, AB, Canada

[28] Inst Nacl Ciencias Med & Nutr Salvador Zubiran, Gastroenterol Unit, Ciudad De Mexico, Mexico

[29] CHU Reims, Dept Hepatogastroenterol, Reims, France

[30] Univ Paris Saclay, Ctr Hepatobiliaire, INSERM Unit UMR 1193, FHU Hepatinov,Hop Paul Brousse, Paris, France

[31] Necmettin Erbakan Univ, Meram Sch Med, Div Gastroenterol, Konya, Turkey

[32] Ankara Univ, Dept Gastroenterol, Med Fac, Ankara, Turkey

[33] Univ Republica, Hosp Clin, Fac Med, Gastroenterol & Hepatol Unit, Montevideo, Uruguay

[34] Gen Univ Hosp Larissa, Natl Expertise Ctr Greece Autoimmune Liver Dis, Dept Med, Larisa, Greece

[35] Gen Univ Hosp Larissa, Natl Expertise Ctr Greece Autoimmune Liver Dis, Res Lab Internal Med, Larisa, Greece

[36] Gen Univ Hosp Larissa, European Reference Network Hepatol Dis ERN RARE L, Larisa, Greece

[37] Hosp Ngeles Pedregal, Hepatol Unit, Ciudad De Mexico, Mexico

[38] Hosp Univ Austral, Hepatol & Liver Transplant Unit, Pilar, Argentina

[39] Mardin State Hosp, Dept Gastroenterol, Mardin, Turkey

[40] Haydarpa Numune Educ & Res Hosp, Dept Gastroenterol, Istanbul, Turkey

[41] Stanford Univ, Div Gastroenterol & Hepatol, Stanford, CA 94305 USA

[42] CEMIC, Ctr Educ Med & Invest Clin, Hepatol Sect, Dept Med, Buenos Aires, DF, Argentina

[43] Karolinska Inst, Dept Upper GI Dis, Hepatol Div, Stockholm, Sweden

[44] Karolinska Univ Hosp, Stockholm, Sweden

来源：

JOURNAL OF AUTOIMMUNITY | 2022年 / 132卷

关键词：

Liver failure; Breakthrough infection; Immunosuppression; Vaccine; Autoimmunity;

D O I：

暂无

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Background: Data regarding outcome of Coronavirus disease 2019 (COVID-19) in vaccinated patients with autoimmune hepatitis (AIH) are lacking. We evaluated the outcome of COVID-19 in AIH patients who received at least one dose of Pfizer-BioNTech (BNT162b2), Moderna (mRNA-1273) or AstraZeneca (ChAdOx1-S) vaccine. Patients and methods: We performed a retrospective study on AIH patients with COVID-19. The outcomes of AIH patients who had acute respiratory syndrome coronavirus 2 (SARS-CoV-2) breakthrough infection after at least one dose of COVID-19 vaccine were compared to unvaccinated patients with AIH. COVID-19 outcome was classified according to clinical state during the disease course as: (i) no hospitalization, (ii) hospitalization without oxygen supplementation, (iii) hospitalization with oxygen supplementation by nasal cannula or mask, (iv) intensive care unit (ICU) admission with non-invasive mechanical ventilation, (v) ICU admission with invasive mechanical ventilation or (vi) death, and data was analyzed using ordinal logistic regression. Results: We included 413 (258 unvaccinated and 155 vaccinated) patients (81%, female) with a median age of 52 (range: 17-85) years at COVID-19 diagnosis. The rates of hospitalization were (36.4% vs. 14.2%), need for any supplemental oxygen (29.5% vs. 9%) and mortality (7% vs. 0.6%) in unvaccinated and vaccinated AIH patients with COVID-19. Having received at least one dose of SARS-CoV-2 vaccine was associated with a significantly lower risk of worse COVID-19 severity, after adjusting for age, sex, comorbidities and presence of cirrhosis (adjusted odds ratio [aOR] 0.18, 95% confidence interval [CI], 0.10-0.31). Overall, vaccination against SARS-CoV-2 was associated with a significantly lower risk of mortality from COVID-19 (aOR 0.20, 95% CI 0.11-0.35). Conclusions: SARS-CoV-2 vaccination significantly reduced the risk of COVID-19 severity and mortality in pa-tients with AIH.

引用

页数：5

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