PHARMACOLOGICAL EVALUATION OF NATURAL PRODUCT ANALOGS .1. PRELIMINARY PHARMACOLOGICAL EVALUATION OF O-METHYLGORTSCHAKOINE AND O-METHYLPETALINE

被引：1

作者：

ALAZIZI, MM ^{[1
]}

ELOLEMY, MM ^{[1
]}

ALHARBI, MM ^{[1
]}

机构：

[1] KING SAUD UNIV,COLL PHARM,DEPT PHARMACOL,RIYADH 11451,SAUDI ARABIA

来源：

PHYTOTHERAPY RESEARCH | 1992年 / 6卷 / 04期

关键词：

O-METHYLGORTSCHAKOINE; O-METHYLPETALINE; HYPOTENSIVE; NEUROMUSCULAR BLOCKING; SMOOTH MUSCLE RELAXANT ACTIONS;

D O I：

10.1002/ptr.2650060412

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

The synthesis of O-methylgortschakoine and O-methylpetaline was achieved through an unambiguous route. Pharmacological testing of O-methylgortschakoine in comparison to papaverine and 7,8-dimethoxy-N-methyltetrahydroisoquinoline, indicated that it possesses hypotensive, neuromuscular blocking and smooth muscle relaxant activities. 7,8-Dimethoxy-N-methyltetrahydroisoquinoline showed only nonspecific smooth muscle relaxation in our testing system. The 1-(p-methoxybenzyl)-substituent of O-methylgortschakoine appears to be required for this hypotensive and neuromuscular blocking effect. The quaternary analogue O-melthylpetaline was found to possess a more potent neuromuscular blocking activity.

引用

页码：221 / 223

页数：3

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