SELECTIVE ENHANCEMENT BY BASIC FIBROBLAST GROWTH-FACTOR OF NMDA RECEPTOR-MEDIATED INCREASE OF INTRACELLULAR CA2+ CONCENTRATION IN HIPPOCAMPAL-NEURONS

被引：17

作者：

ABE, K

SAITO, H

机构：

[1] Department of Chemical Pharmacology, Faculty of Pharmaceutical Sciences, The University of Tokyo, Tokyo

来源：

BRAIN RESEARCH | 1992年 / 595卷 / 01期

关键词：

BASIC FIBROBLAST GROWTH FACTOR; INTRACELLULAR CA2+ CONCENTRATION; HIPPOCAMPAL NEURON; NMDA RECEPTOR; NON-NMDA RECEPTOR; LONG-TERM POTENTIATION;

D O I：

10.1016/0006-8993(92)91461-M

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The short-term effect of bFGF on intracellular Ca2+ concentration ([Ca2+]i) of hippocampal neurons was investigated using dissociated cell cultures. Changes in [Ca2+]i were measured by microfluorometrically monitoring the fluorescence intensities from individual neurons loaded with fura-2. Perfusion of bFGF (20 ng/ml) alone did not affect the basal level of [Ca2+]i in hippocampal neurons, but clearly enhanced the [Ca2+]i increase induced by NMDA. Quisqualate or KCl-induced [Ca2+]i increase was not influenced by bFGF. These results suggest that bFGF selectively enhances the NMDA receptor-mediated response in hippocampal neurons.

引用

页码：128 / 132

页数：5

共 23 条

[1] EFFECTS OF RECOMBINANT HUMAN BASIC FIBROBLAST GROWTH-FACTOR AND ITS MODIFIED PROTEIN CS23 ON SURVIVAL OF PRIMARY CULTURED NEURONS FROM VARIOUS REGIONS OF FETAL-RAT BRAIN [J].