PLATELET BEHAVIOR AND HEMOSTATIC VARIABLES IN TYPE-1 (INSULIN-DEPENDENT) DIABETIC-PATIENTS WITH AND WITHOUT ALBUMINURIA

被引：14
作者：
ODONNELL, MJ [1 ]
LEGUEN, CA [1 ]
LAWSON, N [1 ]
GYDE, OHB [1 ]
BARNETT, AH [1 ]
机构：
[1] E BIRMINGHAM DIST GEN HOSP,UNDERGRAD TEACHING CTR,BORDESLEY GREEN E,BIRMINGHAM B9 5ST,W MIDLANDS,ENGLAND
来源：
DIABETIC MEDICINE | 1991年 / 8卷 / 07期
关键词：
DIABETES-MELLITUS; PLATELETS; BETA-THROMBOGLOBULIN; PLATELET FACTOR-IV ALBUMINURIA; RETINOPATHY; NEPHROPATHY; FIBRINOGEN; FACTOR-VIIIC;
D O I：
10.1111/j.1464-5491.1991.tb01668.x
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Abnormalities of haemostasis have been implicated in the development of both large and small vessel disease in diabetes. Platelet behaviour and coagulation factors were studied in 28 non-diabetic control subjects and 81 Type 1 diabetic patients with different degrees of albuminuria. Twenty-four (30 %) patients had macro- or micro-albuminuria. These patients had elevated levels of beta-thromboglobulin compared with normo-albuminuric patients and control subjects (macro-albuminuric 113 (range 60-314), micro-albuminuric 88 (50-220), normo-albuminuric 55 (13-273), control 52 (18-210)-mu-g l-1, p < 0.001). Similar results were found for platelet factor 4 (macro-albuminuric 57 (9-350), micro-albuminuric 78 (12-205), normo-albuminuric 10 (2-135), control 9 (3-95)-mu-g l-1, p < 0.001). There were decreased beta-thromboglobulin:platelet factor 4 ratios in the albuminuric patients compared with control subjects and normo-albuminuric patients (p < 0.001). There is abnormal platelet activity in Type 1 diabetic patients with elevated albumin excretion rates.
引用
收藏
页码：624 / 628
页数：5
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