SPECIFICITY OF ANTIGEN PROCESSING FOR MHC CLASS-I RESTRICTED PRESENTATION IS CONSERVED BETWEEN MOUSE AND MAN

被引:24
作者
FALK, K [1 ]
ROTZSCHKE, O [1 ]
RAMMENSEE, HG [1 ]
机构
[1] MAX PLANCK INST BIOL, IMMUNGENET ABT, CORRENSSTR 42, W-7400 TUBINGEN, GERMANY
关键词
D O I
10.1002/eji.1830220530
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
Alloreactive mouse cytotoxic T lymphocytes (CTL) specific for particular peptides presented by H-2K(b) molecules on mouse cells were found to recognize human cells transfected with K(b). The CTL-recognized peptides (probably derived from conserved proteins) were extracted from K(b)-expressing human or mouse cells, respectively, and compared biochemically by high resolution high performance liquid chromatography. The results strongly suggest identity of peptides processed by cells from both species and thus indicate that the specificity of the processing machinery used in the major histocompatibility complex (MHC) class I-restricted pathway, probably including enzymes, transport mechanisms, and chaperons, is highly conserved across species. The results are consistent with the notion that MHC molecules themselves have an instructive role in processing.
引用
收藏
页码:1323 / 1326
页数:4
相关论文
共 35 条
  • [1] T-CELLS SENSITIZED TO SYNTHETIC HLA-DR3 PEPTIDE GIVE EVIDENCE OF CONTINUOUS PRESENTATION OF DENATURED HLA-DR3 MOLECULES BY HLA-DP
    DEKOSTER, HS
    ANDERSON, DC
    TERMIJTELEN, A
    [J]. JOURNAL OF EXPERIMENTAL MEDICINE, 1989, 169 (03) : 1191 - 1196
  • [2] DEPLAEN E, 1988, P NATL ACAD SCI USA, V85, P2274
  • [3] MHC CLASS-II REGION ENCODING PROTEINS RELATED TO THE MULTIDRUG RESISTANCE FAMILY OF TRANSMEMBRANE TRANSPORTERS
    DEVERSON, EV
    GOW, IR
    COADWELL, WJ
    MONACO, JJ
    BUTCHER, GW
    HOWARD, JC
    [J]. NATURE, 1990, 348 (6303) : 738 - 741
  • [4] ANTIGEN PRESENTATION - NATURALLY PROCESSED PEPTIDES
    ELLIOTT, T
    TOWNSEND, A
    CERUNDOLO, V
    [J]. NATURE, 1990, 348 (6298) : 195 - 197
  • [5] CELLULAR PEPTIDE COMPOSITION GOVERNED BY MAJOR HISTOCOMPATIBILITY COMPLEX CLASS-I MOLECULES
    FALK, K
    ROTZSCHKE, O
    RAMMENSEE, HG
    [J]. NATURE, 1990, 348 (6298) : 248 - 251
  • [6] IDENTIFICATION OF NATURALLY PROCESSED VIRAL NONAPEPTIDES ALLOWS THEIR QUANTIFICATION IN INFECTED-CELLS AND SUGGESTS AN ALLELE-SPECIFIC T-CELL EPITOPE FORECAST
    FALK, K
    ROTZSCHKE, O
    DERES, K
    METZGER, J
    JUNG, G
    RAMMENSEE, HG
    [J]. JOURNAL OF EXPERIMENTAL MEDICINE, 1991, 174 (02) : 425 - 434
  • [7] ALLELE-SPECIFIC MOTIFS REVEALED BY SEQUENCING OF SELF-PEPTIDES ELUTED FROM MHC MOLECULES
    FALK, K
    ROTZSCHKE, O
    STEVANOVIC, S
    JUNG, G
    RAMMENSEE, HG
    [J]. NATURE, 1991, 351 (6324) : 290 - 296
  • [8] UNEVEN TISSUE DISTRIBUTION OF MINOR HISTOCOMPATIBILITY PROTEINS VERSUS PEPTIDES IS CAUSED BY MHC EXPRESSION
    GRIEM, P
    WALLNY, HJ
    FALK, K
    ROTZSCHKE, O
    ARNOLD, B
    SCHONRICH, G
    HAMMERLING, G
    RAMMENSEE, HG
    [J]. CELL, 1991, 65 (04) : 633 - 640
  • [9] PEPTIDE-DEPENDENT RECOGNITION OF H-2KB BY ALLOREACTIVE CYTO-TOXIC LYMPHOCYTES-T
    HEATH, WR
    HURD, ME
    CARBONE, FR
    SHERMAN, LA
    [J]. NATURE, 1989, 341 (6244) : 749 - 752
  • [10] 2ND PROTEASOME-RELATED GENE IN THE HUMAN MHC CLASS-II REGION
    KELLY, A
    POWIS, SH
    GLYNNE, R
    RADLEY, E
    BECK, S
    TROWSDALE, J
    [J]. NATURE, 1991, 353 (6345) : 667 - 668