ANALGESIC ACTIVITY OF ANTICANCER AGENT SURAMIN

被引：30

作者：

HO, BT ^{[1
]}

HUO, YY ^{[1
]}

LU, JG ^{[1
]}

NEWMAN, RA ^{[1
]}

LEVIN, VA ^{[1
]}

机构：

[1] UNIV TEXAS,MD ANDERSON CANC CTR,DEPT MED ONCOL,HOUSTON,TX 77030

来源：

ANTI-CANCER DRUGS | 1992年 / 3卷 / 02期

关键词：

ANALGESIC ACTIVITY; MORPHINE; NALOXONE; SURAMIN;

D O I：

10.1097/00001813-199204000-00003

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Suramin exhibited morphine-like analgesic activity in mice. It antagonized both thermal (hot-plate) and acetic acid-evoked writhing responses with ED50 values 1/100 and 1/68, respectively, that of morphine. The suramin-and morphine-induced hot-plate analgesia was suppressed by administration of 0.5 mg/kg naloxone. However, lower doses (5-30-mu-g/kg) of naloxone produced dose-related potentiation or suppression of suramin and morphine analgesia. This potentiation effect may be due to the inhibition of writhing by naloxone itself rather than be a direct antagonism of the morphine effect.

引用

页码：91 / 94

页数：4

共 15 条

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