SODIUM-IONS AFFECT ADRENERGIC CONTROL OF SINOATRIAL RATE

被引：6

作者：

COURTNEY, KR ^{[1
]}

JENSEN, RA ^{[1
]}

DAVIS, EE ^{[1
]}

机构：

[1] SRI INT, DIV LIFE SCI, MENLO PK, CA 94025 USA

来源：

JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY | 1979年 / 11卷 / 03期

关键词：

Autonomic effectors; Low sodium; Sinoatrial node; Transmural stimulation;

D O I：

10.1016/0022-2828(79)90438-3

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Electrophysiological techniques were used to monitor sinoatrial rate and its autonomic regulation as lithium and sucrose were substituted for half the sodium in the Tyrode's solution. The autonomic regulation of rate was assessed by transmural stimulation of the nodal region with short electrical shocks, evoking first a cholinergically mediated rate decrease and then a β-adrenergically mediated rate increase. The adrenergic component of the transmural stimulation response was depressed during 10- to 20-min exposures to low Na+; this depression is most likely due to depressed beta-receptor function in low-Na+ solutions. © 1979.

引用

页码：237 / +

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