PHAGOCYTIC FUNCTION OF RETICULOENDOTHELIAL SYSTEM IN RATS TREATED WITH POLYBRENE LIQUOID AND COMPOUND 48/80

被引:4
作者
LAZAR, G
BILICZKI, F
KOVACS, K
机构
[1] Department of Pathophysiology, 1st Department of Medicine, University Medical School, Szeged
关键词
Compound; 48/80; Liquoid®; Polybrene®; RES Phagocytic function;
D O I
10.1159/000135972
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
The phagocytic function of the reticuloendothelial system was studied in rats by India ink clearance and histological examination. Twelve hours fol lowing Ihe intravenous administration of Polybrene or Liquoid the phagocytic activity of Ihe reticuloendothelial system in rats decreased, whereas after treatment with Compound 48/80 it remained unchanged. One hour after injection of Polybrene or Liquoid a significant amount of the intravenously administered India ink was lodged in Ihe lungs. Owing lo Ihe Inlrapulmonary India ink accumulation the phagocytic function of the HKS could not be evaluated at this period. © 1968 S. Karger AG, Basel.
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页码:253 / &
相关论文
共 23 条
[1]  
ALTURA BM, 1967, B NEW YORK ACAD MED, V43, P259
[2]  
BILICZKI F, IN PRESS
[3]  
BIOZZI G, 1953, BRIT J EXP PATHOL, V34, P441
[4]  
CARROLL R, 1964, LANCET, V2, P921
[6]  
GRONVALL JA, 1956, ARCH PATHOL, V62, P324
[7]   MECHANISM OF HISTAMINE RELEASE IN ENDOTOXIN SHOCK [J].
HINSHAW, LB ;
JORDAN, MM ;
VICK, JA .
AMERICAN JOURNAL OF PHYSIOLOGY, 1961, 200 (05) :987-&
[8]  
KIMURA ET, 1961, P SOC EXP BIOL MED, V107, P19
[9]   SOME PHARMACOLOGIC CHARACTERISTICS OF HEXADIMETHRINE BROMIDE (POLYBRENE) - A NEW ANTIHEPARIN AGENT [J].
KIMURA, ET ;
YOUNG, PR ;
STEIN, RJ ;
RICHARDS, RK .
TOXICOLOGY AND APPLIED PHARMACOLOGY, 1959, 1 (02) :185-202
[10]  
KOVACS K, 1967, ACTA MED HUNG, V23, P267